当前位置： SCI文献检索 > COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE期刊下所有文献 > Optimizations of the naïve-Bayes classifier for the prognosis of B-Chronic Lymphocytic Leukemia incorporating flow cytometry data.

Optimizations of the naïve-Bayes classifier for the prognosis of B-Chronic Lymphocytic Leukemia incorporating flow cytometry data.

Abstract：

:Prognosis of B-Chronic Lymphocytic Leukemia (B-CLL) remains a challenging problem in medical research and practice. While the parameters obtained by flow cytometry analysis form the basis of the diagnosis of the disease, the question whether these parameters offer additional prognostic information still remains open. In this work, we attempt to provide computer-assisted support to the clinical experts of the field, by deploying a classification system for B-CLL multiparametric prognosis that combines various heterogeneous (clinical, laboratory and flow cytometry) parameters associated with the disease. For this purpose, we employ the naïve-Bayes classifier and propose an algorithm that improves its performance. The algorithm discretizes the continuous classification attributes (candidate prognostic parameters) and selects the most useful subset of them to optimize the classification accuracy. Thus, in addition to the high classification accuracy achieved, the proposed approach also suggests the most informative parameters for the prognosis. The experimental results demonstrate that the inclusion of flow cytometry parameters in our system improves prognosis.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Lakoumentas J,Drakos J,Karakantza M,Sakellaropoulos G,Megalooikonomou V,Nikiforidis G

doi

10.1016/j.cmpb.2012.02.009

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

158-67

issue

1

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(12)00061-2

journal_volume

108

pub_type

杂志文章

相关文献

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE文献大全
  • Helping doctors hasten COVID-19 treatment: Towards a rescue framework for the transfusion of best convalescent plasma to the most critical patients based on biological requirements via ml and novel MCDM methods.

    abstract：CONTEXT:People who have recently recovered from the threat of deteriorating coronavirus disease-2019 (COVID-19) have antibodies to the coronavirus circulating in their blood. Thus, the transfusion of these antibodies to deteriorating patients could theoretically help boost their immune system. Biologically, two challen...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2020.105617

    authors： Albahri OS,Al-Obaidi JR,Zaidan AA,Albahri AS,Zaidan BB,Salih MM,Qays A,Dawood KA,Mohammed RT,Abdulkareem KH,Aleesa AM,Alamoodi AH,Chyad MA,Zulkifli CZ

    更新日期：2020-11-01 00:00:00

  • Epileptic EEG detection using neural networks and post-classification.

    abstract：:Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2008.02.005

    authors： Patnaik LM,Manyam OK

    更新日期：2008-08-01 00:00:00

  • Automated quantitative analysis of angiogenesis in the rat aorta model using Image-Pro Plus 4.1.

    abstract：:This paper explains the automated image-processing steps for the quantification of microvascular growth formation in the rat thoracic aortic ring model, an ex vivo model using excised rings of rat aorta embedded in a collagen matrix which produce outgrowths of microvessels. This model of angiogenesis is useful to stud...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2003.11.001

    authors： Blatt RJ,Clark AN,Courtney J,Tully C,Tucker AL

    更新日期：2004-07-01 00:00:00

  • Effect of power feature covariance shift on BCI spatial-filtering techniques: A comparative study.

    abstract：BACKGROUND AND OBJECTIVE:The input data distributions of EEG-based BCI systems can change during intra-session transitions due to nonstationarity caused by features covariate shifts, thus compromising BCI performance. We aimed to identify the most robust spatial filtering approach, among most used methods, testing them...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2020.105808

    authors： Miladinović A,Ajčević M,Jarmolowska J,Marusic U,Colussi M,Silveri G,Battaglini PP,Accardo A

    更新日期：2021-01-01 00:00:00

  • Accelerated event-by-event Monte Carlo microdosimetric calculations of electrons and protons tracks on a multi-core CPU and a CUDA-enabled GPU.

    abstract：:For microdosimetric calculations event-by-event Monte Carlo (MC) methods are considered the most accurate. The main shortcoming of those methods is the extensive requirement for computational time. In this work we present an event-by-event MC code of low projectile energy electron and proton tracks for accelerated mic...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2013.09.009

    authors： Kalantzis G,Tachibana H

    更新日期：2014-01-01 00:00:00

  • Evaluation of Epilepsy Expert--a decision support system.

    abstract：:Epilepsy Expert is a decision support system based on the International Classification of Epilepsies and Epileptic Syndromes (1989). The aim of this study was to evaluate the Epilepsy Expert. First the diagnostic performance was validated. This was done in 3 stages: collection of the patient cases, determination of th...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(94)90206-2

    authors： Korpinen L,Pietilä T,Peltola J,Nissilä M,Keränen T,Touvinen T,Falck B,Petránek ES,Frey H

    更新日期：1994-11-01 00:00:00

  • Development and use of a Cytoscape app for GRNCOP2.

    abstract：BACKGROUND AND OBJECTIVE:Gene regulatory networks (GRNs) are essential for understanding most molecular processes. In this context, the so-called model-free approaches have an advantage modeling the complex topologies behind these dynamic molecular networks, since most GRNs are difficult to map correctly by any other m...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2019.05.030

    authors： Díaz-Montaña JJ,Díaz-Díaz N,Barranco CD,Ponzoni I

    更新日期：2019-08-01 00:00:00

  • An approach based on wavelet analysis for feature extraction in the a-wave of the electroretinogram.

    abstract：:Most biomedical signals are non-stationary. The knowledge of their frequency content and temporal distribution is then useful in a clinical context. The wavelet analysis is appropriate to achieve this task. The present paper uses this method to reveal hidden characteristics and anomalies of the human a-wave, an import...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2011.05.001

    authors： Barraco R,Persano Adorno D,Brai M

    更新日期：2011-12-01 00:00:00

  • An expert system for the nutritional management of the critically ill.

    abstract：:While there have been considerable advances in the last several years in the nutritional management of the critically ill, these improvements are not always recognized in intensive care environments. In this paper we describe the development and testing of an expert system, NUTRITIONAL ADVISOR, which would be be an ai...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(90)90040-g

    authors： Fraser RB,Turney SZ

    更新日期：1990-11-01 00:00:00

  • Profiling intra-patient type I diabetes behaviors.

    abstract：BACKGROUND:The large intra-patient variability in type 1 diabetic patients dramatically reduces the ability to achieve adequate blood glucose control. A novel methodology to identify different blood glucose dynamics profiles will allow therapies to be more accurate and tailored according to patient's conditions and to ...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2016.08.022

    authors： Contreras I,Quirós C,Giménez M,Conget I,Vehi J

    更新日期：2016-11-01 00:00:00

  • Metabolica: a statistical research tool for analyzing metabolic networks.

    abstract：:Steady state flux balance analysis (FBA) for cellular metabolism is used, e.g., to seek information on the activity of the different pathways under equilibrium conditions, or as a basis for kinetic models. In metabolic models, the stoichiometry of the system, commonly completed with bounds on some of the variables, is...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2009.07.007

    authors： Heino J,Calvetti D,Somersalo E

    更新日期：2010-02-01 00:00:00

  • Pivoting approaches for bulk extraction of Entity-Attribute-Value data.

    abstract：:Entity-Attribute-Value (EAV) data, as present in repositories of clinical patient data, must be transformed (pivoted) into one-column-per-parameter format before it can be used by a variety of analytical programs. Pivoting approaches have not been described in depth in the literature, and existing descriptions are dat...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2006.02.001

    authors： Dinu V,Nadkarni P,Brandt C

    更新日期：2006-04-01 00:00:00

  • Enhancement of surgical hand gesture recognition using a capsule network for a contactless interface in the operating room.

    abstract：BACKGROUND AND OBJECTIVE:Hand gesture recognition systems in operating rooms (ORs) are crucial for browsing and controlling computer-aided devices, which have been developed to decrease the risk of contamination during surgical procedures. METHODS:We proposed the use of hand gesture recognition to enhance accuracies a...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2020.105385

    authors： Lee AR,Cho Y,Jin S,Kim N

    更新日期：2020-07-01 00:00:00

  • DILEMMA: logic engineering in primary care, shared care and oncology (AIM Project A2005).

    abstract：:The aim of DILEMMA is to provide tools for the development of decision support systems for use in general medical practice, hospital-based cancer care, and shared care of cancer and cardiology patients. In primary care, the project intends to provide aids to clinical performance in prescribing, referral and the use of...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(94)90011-6

    authors： Gordon C,Jackson-Smale A,Thomson R

    更新日期：1994-10-01 00:00:00

  • BE-DTI': Ensemble framework for drug target interaction prediction using dimensionality reduction and active learning.

    abstract：BACKGROUND AND OBJECTIVE:Drug-target interaction prediction plays an intrinsic role in the drug discovery process. Prediction of novel drugs and targets helps in identifying optimal drug therapies for various stringent diseases. Computational prediction of drug-target interactions can help to identify potential drug-ta...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2018.08.011

    authors： Sharma A,Rani R

    更新日期：2018-10-01 00:00:00

  • MSurvPow: a FORTRAN program to calculate the sample size and power for cluster-randomized clinical trials with survival outcomes.

    abstract：:Manatunga and Chen [A.K. Manatunga, S. Chen, Sample size estimation for survival outcomes in cluster-randomized studies with small cluster sizes, Biometrics 56 (2000) 616-621] proposed a method to estimate sample size and power for cluster-randomized studies where the primary outcome variable was survival time. The sa...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2004.11.004

    authors： Gao F,Manatunga AK,Chen S

    更新日期：2005-04-01 00:00:00

  • An intelligent support system for automatic detection of cerebral vascular accidents from brain CT images.

    abstract：OBJECTIVE:This paper presents a Radial Basis Functions Neural Network (RBFNN) based detection system, for automatic identification of Cerebral Vascular Accidents (CVA) through analysis of Computed Tomographic (CT) images. METHODS:For the design of a neural network classifier, a Multi Objective Genetic Algorithm (MOGA)...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2017.05.005

    authors： Hajimani E,Ruano MG,Ruano AE

    更新日期：2017-07-01 00:00:00

  • A drug-to-drug interaction package.

    abstract：:This paper describes an electronic database for handling the interactions between active principles administered to various patients. The computer used is a personal computer with adequate mass memory, software, and data obtained from pharmacological sources. The main features of this work are: 'all-patient' orientati...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(89)90147-8

    authors： Pinciroli F,Pozzi G

    更新日期：1989-03-01 00:00:00

  • Classification of auditory selective attention using spatial coherence and modular attention index.

    abstract：BACKGROUND AND OBJECTIVE:Brain-Computer Interfaces (BCIs) based on auditory selective attention have been receiving much attention because i) they are useful for completely paralyzed users since they do not require muscular effort or gaze and ii) focusing attention is a natural human ability. Several techniques - such ...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2018.10.002

    authors： de Souza AP,Soares QB,Felix LB,Mendes EMAM

    更新日期：2018-11-01 00:00:00

  • Evaluation of a smartphone-based assessment system in subjects with chronic ankle instability.

    abstract：BACKGROUND:Ankle sprain is the most common sports-related injury, and approximately 80% of patients studied suffered recurrent sprains. These repeated ankle injuries could cause chronic ankle instability, a decrease in sports performance, and a decrease in postural control ability. At the present time, smartphones have...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2016.11.005

    authors： Chiu YL,Tsai YJ,Lin CH,Hou YR,Sung WH

    更新日期：2017-02-01 00:00:00

  • Computer-assisted centrifugal elutriation. II. Multiparametric statistical analysis.

    abstract：:A combination of non-interactive statistical methods is discussed to analyze multiparametric light-scatter data obtained by means of computer-assisted centrifugal elutriation. ...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(88)90101-0

    authors： Sloot PM,Van der Donk EH,Figdor CG

    更新日期：1988-07-01 00:00:00

  • Microcomputer program for the assessment of one-way, two-way and factorial analysis of variance in pharmaceutical data.

    abstract：:A personal computer program in BASIC for the two-factor factorial analysis of variance has been developed. The factorial design is based on and combined with previous one-way and two-way ANOVA programs. The performance of the program is tested on data obtained from 3 months' consumption of three proprietary antibiotic...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(93)90072-s

    authors： Abdullah ME,al-Khamis KI

    更新日期：1993-12-01 00:00:00

  • Classification of THz pulse signals using two-dimensional cross-correlation feature extraction and non-linear classifiers.

    abstract：:This work provides a performance comparison of four different machine learning classifiers: multinomial logistic regression with ridge estimators (MLR) classifier, k-nearest neighbours (KNN), support vector machine (SVM) and naïve Bayes (NB) as applied to terahertz (THz) transient time domain sequences associated with...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2016.01.017

    authors： Siuly,Yin X,Hadjiloucas S,Zhang Y

    更新日期：2016-04-01 00:00:00

  • Comparison and validation of capacitive accelerometers for health care applications.

    abstract：:Fall detection, gait analysis and context recognition are examples of applications where capacitive accelerometers are widely used in health care. In most of the existing work, algorithms were developed for a specific platform and accelerometers were used without explicitly choosing a specific type. With this work we ...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2011.10.009

    authors： Büsching F,Kulau U,Gietzelt M,Wolf L

    更新日期：2012-05-01 00:00:00

  • Voice controlled wheelchairs: fine control by humming.

    abstract：:People without disabilities seamlessly control devices with their hands. Interestingly, their hands can perform coarse and fine control. Implementing smooth control for computerized systems is not straightforward and most of the time it is not intuitive either. Here we offer a solution to that problem: smooth control ...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2013.06.009

    authors： Peixoto N,Nik HG,Charkhkar H

    更新日期：2013-10-01 00:00:00

  • SOA-based digital library services and composition in biomedical applications.

    abstract：:Carefully collected, high-quality data are crucial in biomedical visualization, and it is important that the user community has ready access to both this data and the high-performance computing resources needed by the complex, computational algorithms that will process it. Biological researchers generally require data...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2010.08.009

    authors： Zhao X,Liu E,Clapworthy GJ,Viceconti M,Testi D

    更新日期：2012-06-01 00:00:00

  • A tracer metric numerical model for predicting tortuosity factors in three-dimensional porous tissue scaffolds.

    abstract：:One of the critical functions of a tissue-engineered construct is to be able to provide adequate nutrient and oxygen supply into the interior of the construct. An insufficient supply will lead to slower cellular proliferation rates and eventual apoptosis. The supply of the nutrients is largely governed by the transpor...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2007.04.003

    authors： Starly B,Yildirim E,Sun W

    更新日期：2007-07-01 00:00:00

  • The importance of proper seeding of the Applesoft pseudorandom number generator.

    abstract：:The popularity of the use of Apple II/IIe hardware in medical applications is evidenced by the variety of articles devoted to the use of this hardware in biomedical research and medical practice. Many of these applications are of a stochastic nature, including simulations, and depend on the Applesoft random number gen...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(88)90002-8

    authors： Gleason JM

    更新日期：1988-05-01 00:00:00

  • The role of AIDA in a primary care information system.

    abstract：:In this article the development of a computer system for General Practice, ELIAS, is described. The use of the 4th-generation software toolkit AIDA proved to be very helpful in increasing the speed of development as well as the quality of the ELIAS software. The programming support that AIDA offered, not only in incre...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/0169-2607(87)90086-1

    authors： Boon WM,Westerhof HP,Duisterhout JS,Cromme PV

    更新日期：1987-11-01 00:00:00

  • Entropy analysis of muscular near-infrared spectroscopy (NIRS) signals during exercise programme of type 2 diabetic patients: quantitative assessment of muscle metabolic pattern.

    abstract：:Diabetes mellitus (DM) is a metabolic disorder that is widely rampant throughout the world population these days. The uncontrolled DM may lead to complications of eye, heart, kidney and nerves. The most common type of diabetes is the type 2 diabetes or insulin-resistant DM. Near-infrared spectroscopy (NIRS) technology...

    journal_title：Computer methods and programs in biomedicine

    pub_type： 杂志文章

    doi：10.1016/j.cmpb.2013.08.018

    authors： Molinari F,Acharya UR,Martis RJ,De Luca R,Petraroli G,Liboni W

    更新日期：2013-12-01 00:00:00