当前位置： SCI文献检索 > COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE期刊下所有文献 > BE-DTI': Ensemble framework for drug target interaction prediction using dimensionality reduction and active learning.

BE-DTI': Ensemble framework for drug target interaction prediction using dimensionality reduction and active learning.

Abstract：

BACKGROUND AND OBJECTIVE:Drug-target interaction prediction plays an intrinsic role in the drug discovery process. Prediction of novel drugs and targets helps in identifying optimal drug therapies for various stringent diseases. Computational prediction of drug-target interactions can help to identify potential drug-target pairs and speed-up the process of drug repositioning. In our present, work we have focused on machine learning algorithms for predicting drug-target interactions from the pool of existing drug-target data. The key idea is to train the classifier using existing DTI so as to predict new or unknown DTI. However, there are various challenges such as class imbalance and high dimensional nature of data that need to be addressed before developing optimal drug-target interaction model. METHODS:In this paper, we propose a bagging based ensemble framework named BE-DTI' for drug-target interaction prediction using dimensionality reduction and active learning to deal with class-imbalanced data. Active learning helps to improve under-sampling bagging based ensembles. Dimensionality reduction is used to deal with high dimensional data. RESULTS:Results show that the proposed technique outperforms the other five competing methods in 10-fold cross-validation experiments in terms of AUC=0.927, Sensitivity=0.886, Specificity=0.864, and G-mean=0.874. CONCLUSION:Missing interactions and new interactions are predicted using the proposed framework. Some of the known interactions are removed from the original dataset and their interactions are recalculated to check the accuracy of the proposed framework. Moreover, validation of the proposed approach is performed using the external dataset. All these results show that structurally similar drugs tend to interact with similar targets.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Sharma A,Rani R

doi

10.1016/j.cmpb.2018.08.011

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

151-162

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(18)30868-X

journal_volume

165

pub_type

杂志文章

在线工具

BE-DTI': Ensemble framework for drug target interaction prediction using dimensionality reduction and active learning.