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GREMET: an integrative tool for the prediction of mutation effects on gene regulation.

Abstract：

:The identification of thousands of mutations yearly has put new challenges to researchers who are interested in fast and effective annotation as well as the prediction of potential implications to the gene regulation mechanisms. This work presents an integrative tool, called GREMET, for the prediction of alterations in gene splicing regulation inferred by mutations of the human genome. GREMET supports the characterization of mutations either single-point or indels with respect to their effect on the splicing potential of the neighboring sequences and the binding strength of auxiliary cis-acting splicing enhancers. In addition, GREMET identifies possible consequences of mutations on the DNA methylation through the disruption or creation of CpG sequences. Besides locus-specific mutations, GREMET performs the analyses on newly identified mutations and provides an easy-to-use Web interface helping researchers to save time in routine mutation analyses. GREMET is freely accessible at: http://kedip.med.auth.gr/biotools/gremet/.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Athanasiadis P,Malousi A,Kouidou S,Maglaveras N

doi

10.1016/j.cmpb.2013.04.002

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

214-9

issue

1

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(13)00108-9

journal_volume

111

pub_type

杂志文章

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