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Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance.

Abstract：

:Glucose-insulin system models are commonly used for identifying insulin sensitivity. With physiological, 2-compartment insulin kinetics models, accurate kinetic parameter values are required for reliable estimates of insulin sensitivity. This study uses data from 6 published microdialysis studies to determine the most appropriate parameter values for the transcapillary diffusion rate (n(I)) and cellular insulin clearance rate (n(C)). The 6 studies (12 data sets) used microdialysis techniques to simultaneously obtain interstitial and plasma insulin concentrations. The reported plasma insulin concentrations were used as input and interstitial insulin concentrations were simulated with the interstitial insulin kinetics sub-model. These simulated results were then compared to the reported interstitial measurements and the most appropriate set of parameter values was determined across the 12 data sets by combining the results. Interstitial insulin kinetic parameters values n(I)=n(C)=0.0060 min⁻¹ were shown to be the most appropriate. These parameter values are associated with an effective, interstitial insulin half-life, t(½)=58 min, within the range of 25-130 min reported by others.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Pretty CG,Le Compte A,Penning S,Fisk L,Shaw GM,Desaive T,Chase JG

doi

10.1016/j.cmpb.2014.01.011

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

e39-45

issue

3

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(14)00023-6

journal_volume

114

pub_type

杂志文章

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