Abstract：
:The assessment of sample size in clinical trials comparing means requires a variance estimate of the main efficacy variable. If no reliable information about the variance of the key response is available at the beginning of a clinical trial, the use of data from the first 'few' patients entered in the trial ('internal pilot') may be appropriate to estimate the variance and thus to recalculate the required sample size. A SAS macro that implements the EM algorithm for carrying out and simulating such interim power evaluations without unblinding the treatment status is presented.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Zellner D,Zellner GE,Keller Fdoi
10.1016/s0169-2607(00)00119-xsubject
Has Abstractpub_date
2001-06-01 00:00:00pages
183-90issue
3eissn
0169-2607issn
1872-7565pii
S016926070000119Xjournal_volume
65pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVES:Empirical antimicrobial prescription strategies have been proposed to counteract the selection of resistant pathogenic strains. The respective merits of such strategies have been debated. Rather than comparing a finite number of policies, we take an optimization approach and propose a solution...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105767
更新日期：2021-01-01 00:00:00
abstract：:Lumped parameter approaches for modelling the cardiovascular system typically have many parameters of which a significant percentage are often not identifiable from limited data sets. Hence, significant parts of the model are required to be simulated with little overall effect on the accuracy of data fitting, as well ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.01.002
更新日期：2010-07-01 00:00:00
abstract：:This study employs the concept of applying constant-phase models to input respiratory impedance data obtained with the non-invasive Forced Oscillation Technique (FOT) lung function test. Changes in respiratory mechanics from healthy and chronic obstructive pulmonary disease (COPD) diagnosed patients are observed with ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.06.006
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Standardization of the carotid IMT requires a reference marker in ultrasound scans. It has been shown previously that manual reference marker and manually created carotid segments are used for measuring IMT in these segments. Manual methods are tedious, time consuming, subjective, and prone to...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.01.009
更新日期：2017-04-01 00:00:00
abstract：:We propose a specially optimized computer program for the user-independent calculation of the correlation dimension D and the largest Lyapunov exponent L of heart rate dynamics on the basis of only 1024 electrocardiographically recorded RR intervals (heartbeat intervals). The validity of our program was established by...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章
doi：10.1016/0169-2607(95)01707-0
更新日期：1996-01-01 00:00:00
abstract：:Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide. Such atlases have been built from diffusion tensor (DT) images and can be used in anisotropic models for personalized...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105200
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Automated segmentation with high accuracy and speed is a prerequisite for FEA-based quantitative assessment with a large population. However, hip joint segmentation has remained challenging due to a narrow articular cartilage and thin cortical bone with a marked interindividual variance. To ove...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.007
更新日期：2018-02-01 00:00:00
abstract：:This research project sought to design and implement a computerized clinical decision support system (CDSS) that was able to identify patients who were at risk of pulmonary embolism (PE) and deep vein thrombosis (DVT), as well as produce reminders for prophylactic action for these diseases. The main purpose of the CDS...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2014.03.007
更新日期：2014-07-01 00:00:00
abstract：:Diabetes mellitus (DM) is a metabolic disorder that is widely rampant throughout the world population these days. The uncontrolled DM may lead to complications of eye, heart, kidney and nerves. The most common type of diabetes is the type 2 diabetes or insulin-resistant DM. Near-infrared spectroscopy (NIRS) technology...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.08.018
更新日期：2013-12-01 00:00:00
abstract：:We discuss how vocal disorders can be post-corrected via a simple nonlinear noise reduction scheme. This work is motivated by the need of a better understanding of voice dysfunctions. This would entail a 2-fold advantage for affected patients: Physicians can perform better surgical interventions and on the other hand ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00161-4
更新日期：2002-05-01 00:00:00
abstract：:In modern molecular biology, high-throughput experiments allow the simultaneous study of expression levels of thousands of biopolymers such as mRNAs, miRNAs or proteins. A typical goal of such experiments is to find molecular signatures that can distinguish between different types of tissue or that can predict a thera...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.013
更新日期：2013-09-01 00:00:00
abstract：:As health care costs have risen dramatically, the use of clinical data to analyze the quality of health care provided has increased. Central to this analysis is the means by which the clinical data itself is obtained. The reliability and validity of the data must be established in order to insure credible use of the d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(93)90063-q
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Early detection of cardiovascular (CV) disease or associated risk factors during childhood is of paramount importance, allowing for early treatment or lifestyle modifications, respectively. The objective of this study was to describe the development of an electronic health record (EHR), with in...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：:This paper presents a preprocessing technique for improving the classification of electroencephalographic (EEG) data in brain-computer interfaces (BCI) for the case of realistic measuring conditions, such as low signal-to-noise ratio (SNR), reduced number of measuring electrodes, and reduced amount of data used to tra...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.05.005
更新日期：2010-01-01 00:00:00
abstract：:Mixed-effects model is an efficient tool for analyzing longitudinal data. The random effects in a mixed-effects model can be used to capture the correlations among repeated measurements within a subject. Mixed effects model can be used to describe individual response profile as well as population response profile. In ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.11.007
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Respiratory gating training is a common technique to increase patient proprioception, with the goal of (e.g.) minimizing the effects of organ motion during radiotherapy. In this work, we devise a system based on autoencoders for classification of regular, apnea and unconstrained breathing patte...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105675
更新日期：2020-10-01 00:00:00
abstract：:Following the paper publication of practice guidelines for the management of febrile patients returning from the tropics, we constructed a consultation website that comprises a decision chart and specific diagnostic features providing medical diagnostic assistance to primary care physicians. We then integrated a resea...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.09.004
更新日期：2007-01-01 00:00:00
abstract：:Selecting appropriate ventilator settings decreases the risk of ventilator-induced lung injury. A decision support system (DSS) has been developed based on physiological models, which can advise on setting of tidal volume (Vt), respiratory frequency (f) and fraction of inspired oxygen (FiO2). The aim of this study is ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.07.001
更新日期：2008-11-01 00:00:00
abstract：:The increasing use of computer systems for storing patient information in different hospitals, in different departments within the same hospital, in clinics and even in doctors' surgeries, is creating a problem in terms of the fragmentation of the patient record. The lack of any coordination or standardization in the ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90080-9
更新日期：1994-06-01 00:00:00
abstract：:We have designed and implemented a human brain multi-modality database system with content-based image management, navigation and retrieval support for epilepsy. The system consists of several modules including a database backbone, brain structure identification and localization, segmentation, registration, visual fea...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.012
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:The application of entropy optimization has consistently incorporated in traditional and industrial fields. The system is permanently sustainable, usually a final ideal structure may not exist in general, as common evolution shows trends in a long time. The measurement of the entropy generation related to he...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105262
更新日期：2020-05-01 00:00:00
abstract：:A personal computer program in BASIC for the two-factor factorial analysis of variance has been developed. The factorial design is based on and combined with previous one-way and two-way ANOVA programs. The performance of the program is tested on data obtained from 3 months' consumption of three proprietary antibiotic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(93)90072-s
更新日期：1993-12-01 00:00:00
abstract：:This article presents a method of predictive simulation, patient-dependant, in real time of the abdominal organ positions during free breathing. The method, that considers both influence of the abdominal breathing and thoracic breathing, needs a tracking of the patient skin and a model of the patient-specific modifica...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.03.003
更新日期：2010-11-01 00:00:00
abstract：:Atrial fibrillation (AF) is the commonest arrhythmia, yet the mechanisms of its onset and persistence are incompletely known. Although techniques for quantitative assessment have been investigated, there have been few attempts to integrate this information to advance disease treatment protocols. In this review, key qu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2019.06.017
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Signal segmentation and spike detection are two important biomedical signal processing applications. Often, non-stationary signals must be segmented into piece-wise stationary epochs or spikes need to be found among a background of noise before being further analyzed. Permutation entropy (PE) h...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.02.008
更新日期：2016-05-01 00:00:00
abstract：:Tokyo Hitachi Hospital, Hitachi Ltd., has used a hospital-wide PACS for over 1 year. The system runs a 100 Mb/s optical fiber network over the whole hospital including wards and outpatient clinic rooms, with 11 image workstations. The network links digital imaging modalities such as X-CT, MRI, computed radiography (CR...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90190-2
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.08.011
更新日期：2017-11-01 00:00:00
abstract：:Diabetic retinopathy (DR) is one of the most important complications of diabetes mellitus, which causes serious damages in the retina, consequently visual loss and sometimes blindness if necessary medical treatment is not applied on time. One of the difficulties in this illness is that the patient with diabetes mellit...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.06.007
更新日期：2012-08-01 00:00:00
abstract：:Topological thinning is a valid but time-consuming method to calculate the centerline of human colon or other hollow organs accurately. An optimized 3D topological thinning method based on Look-up Table (LUT), which was proposed by Sadlier, proves to be effective in improving the efficiency on many occasions. However,...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.10.002
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Atrial fibrillation (AF) is a type of arrhythmia with high incidence. Automatic AF detection methods have been studied in previous works. However, a model cannot be used all the time without any improvement. And updating model requires adequate data and cost. Therefore, this study aims at findi...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105219
更新日期：2020-04-01 00:00:00
