Abstract：
:The aim of this study was to provide numerical evidence that latanoprost induced iris darkening (LIID) can be caused by changes to the melanin granule size distribution in the anterior segment of the iris. Iridectomies from two patients were used, where both had undergone unilateral treatment with latanoprost and had exhibited LIID. The untreated eye provided the comparative control. Micrographs from the iris samples were analysed to determine the number and size of the mature melanin granules. Monte Carlo (MC) simulation of light propagation in the iris was performed to examine the changes in reflectance and absorption with varying particle size and density. The reflected intensity of light was obtained as a function of wavelength. CIE colour theory was employed in order to estimate a perceived colour from the reflectance data. MC simulations showed that the reflectance was reduced for the LIID irises compared to the control irises for both subjects and for all wavelengths of light. The MC simulated colours were in good agreement with the in vivo photography of the eye colour. Hence, we have demonstrated that increases in melanin granule size causes iris darkening, and can explain LIID.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Cracknell KP,Farnell DJ,Grierson Idoi
10.1016/j.cmpb.2007.04.010subject
Has Abstractpub_date
2007-08-01 00:00:00pages
93-103issue
2eissn
0169-2607issn
1872-7565pii
S0169-2607(07)00106-Xjournal_volume
87pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Cerebrovascular diseases (CVDs) affect a large number of patients and often have devastating outcomes. The hallmarks of CVDs are the abnormalities formed on brain blood vessels, including protrusions, narrows, widening, and bifurcation of the blood vessels. CVDs are often diagnosed by digital s...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105159
更新日期：2020-03-01 00:00:00
abstract：:A computer program for a microcomputer (HP 86) is presented to discriminate between different models and to design new experiments for model discrimination. By a non-linear fitting algorithm a set of experimental data is fitted with different models suggested by the user. The parameters characterizing each model are e...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90022-2
更新日期：1986-04-01 00:00:00
abstract：:This paper presents a preprocessing technique for improving the classification of electroencephalographic (EEG) data in brain-computer interfaces (BCI) for the case of realistic measuring conditions, such as low signal-to-noise ratio (SNR), reduced number of measuring electrodes, and reduced amount of data used to tra...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.05.005
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Atherosclerosis is a degenerative disease of the arterial wall. It results in the formation of progressively growing plaque lesions that can harden and narrow their host arteries. Current computational models of the inflammatory process that govern atherosclerosis growth are reliant on a number of parameters...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105904
更新日期：2020-12-17 00:00:00
abstract：:Rapid and accurate discrimination of single units from extracellular recordings is a fundamental process for the analysis and interpretation of electrophysiological recordings. We present an algorithm that performs detection, characterization, discrimination, and analysis of action potentials from extracellular record...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.07.001
更新日期：2004-12-01 00:00:00
abstract：:Enhanced modified moving average method (EMMAM) and correlation method (CM) for microvolt TWA identification are compared by aid of simulated ECG tracings (cases of absence of TWA and presence of stationary or time-varying TWA) and ECG recordings from healthy subjects (H-group) and patients who survived an acute myoca...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.01.008
更新日期：2010-04-01 00:00:00
abstract：:The long-term variability of the fetal heart rate (FHR) provides valuable information on the fetal health status. The routine clinical FHR measurements are usually carried out by the means of ultrasound cardiography. Although the frequent FHR monitoring is recommendable, the high quality ultrasound devices are so expe...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(02)00111-6
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In recent years, many attempts have been made to design reliable systems for identifying individuals using biometrics. Electrocardiogram (ECG) biometric is one of the newest methods that not only offers unique characteristics of individuals for human identification, but also the possibility of ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.02.009
更新日期：2019-04-01 00:00:00
abstract：:We have designed and implemented a human brain multi-modality database system with content-based image management, navigation and retrieval support for epilepsy. The system consists of several modules including a database backbone, brain structure identification and localization, segmentation, registration, visual fea...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.012
更新日期：2005-09-01 00:00:00
abstract：:Glaucoma is a destructive eye disease that causes blindness in individuals displaying little or no symptoms. There is no cure as yet though there are treatments that can arrest its effects or slow its development. The earlier the disease is detected, the more likely the treatment will be successful; however early dete...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.01.002
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Shape prior models play a vital role for segmentation in medical image analysis. These models are most effective when shape variations can be captured by a parametric distribution, and sufficient training data is available. However, in the absence of these conditions, results are invariably muc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105760
更新日期：2020-09-24 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Frozen-thawed embryo transfer (FET) is now widely used for the treatment of infertility. For many couples and clinicians, concerns over the probability and how to increase the chance of a successful birth are very common. Currently, there is not a single model to predict the live birth outcomes...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105780
更新日期：2021-01-01 00:00:00
abstract：:Cloud computing and the Internet of Things are the two hot points in the Internet application field. The application of the two new technologies is in hot discussion and research, but quite less on the field of medical monitoring and managing application. Thus, in this paper, we study and analyze the application of cl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：:The computer program MISCAN is developed for use in evaluation of mass screening for disease. The program uses Monte Carlo simulation. It produces output on the results of screening projects and on the effects of screening on morbidity and mortality on the individual and population level. The calculations are based on...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(85)90048-3
更新日期：1985-05-01 00:00:00
abstract：:Diabetic retinopathy (DR) is one of the most important complications of diabetes mellitus, which causes serious damages in the retina, consequently visual loss and sometimes blindness if necessary medical treatment is not applied on time. One of the difficulties in this illness is that the patient with diabetes mellit...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.06.007
更新日期：2012-08-01 00:00:00
abstract：:In this study a novel approach based on 2D FIR filters is presented for denoising digital images. In this approach the filter coefficients of 2D FIR filters were optimized using the Artificial Bee Colony (ABC) algorithm. To obtain the best filter design, the filter coefficients were tested with different numbers (3×3,...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.009
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The presence of circulating tumor cells in the patient's blood is a clinical factor that indicates the initiation of metastasis. METHODS:In this paper, a microfluidic device is designed to separate, enumerate, and to diagnose cancer cells from the patient's blood sample. Here, we present a new...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105147
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Structural changes of the brain's third ventricle have been acknowledged as an indicative measure of the brain atrophy progression in neurodegenerative and endocrinal diseases. To investigate the ventricular enlargement in relation to the atrophy of the surrounding structures, shape analysis is a promising a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.02.014
更新日期：2016-06-01 00:00:00
abstract：:Due to organizational and technological changes the need for integrating information systems within healthcare institutions, has increased enormously. Although the technical means for systems integration have definitely matured, integration methodologies are still in their infancy. Two important questions regarding sy...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00086-9
更新日期：2001-01-01 00:00:00
abstract：:A flexible program for the IBM PC performing a number of calculations of relevance for the prescription of hemodialysis treatment has been developed. The program has a 'spreadsheet'-like user-friendly interface, and results may be presented graphically. The present implementation covers 89 algorithms/equations, all ba...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90009-x
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:A new expert system is proposed to discriminate healthy people from people with Parkinson's Disease (PD) in early stages by using Diadochokinesis tests. METHODS:The system is based on temporal and spectral features extracted from the Voice Onset Time (VOT) segments of /ka/ syllables, whose bou...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.010
更新日期：2018-02-01 00:00:00
abstract：:A PC-based real-time quality control (QC) system for multitest analyzers has been developed as a prototype. The system is built with use of a relational database management system (DBMS). Control values from the various analytical channels are stored and administrated with use of the DBMS. The control values collected...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90042-r
更新日期：1991-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In Duchenne Muscular Dystrophy (DMD) treatment, muscle fiber size can be considered as an indicator of muscle health and function. In particular, the statistical distribution of fibers cross-sectional areas (CSAs) has been used as quantitative efficacy endpoint. For each patient, assessment of ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.06.002
更新日期：2019-09-01 00:00:00
abstract：:A Monte Carlo model of steady-state light transport in multi-layered tissues (MCML) has been coded in ANSI Standard C; therefore, the program can be used on various computers. Dynamic data allocation is used for MCML, hence the number of tissue layers and grid elements of the grid system can be varied by users at run ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(95)01640-f
更新日期：1995-07-01 00:00:00
abstract：:This paper presents the control system design of a rehabilitation and training robot for the upper limbs. Based on a hierarchical structure, this control system allows the execution of sequence of switching control laws (position, force, impedance and force/impedance) corresponding to the required training configurati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.07.006
更新日期：2008-02-01 00:00:00
abstract：:Several approaches, based on different assumptions and with various degree of theoretical sophistication and implementation complexity, have been developed for improving the measurement of evoked potentials (EP) performed by conventional averaging (CA). In many of these methods, one of the major challenges is the expl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00175-4
更新日期：2002-06-01 00:00:00
abstract：:One approach of improving metabolic control in type I diabetic patients is the application of computer-aided procedures aimed at supporting the decision on optimal therapeutic regimens. To accomplish this, a complex strategy was developed which in an individual patient permits (1) the evaluation of metabolic data by m...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90103-g
更新日期：1990-07-01 00:00:00
abstract：:The purpose of this study was to evaluate the clinical efficacy of 3D reconstruction of the tracheobronchial system using spiral CT. A total of 25 patients with tracheobronchial abnormalities, stenosis (n = 21) and fistula with esophagus (n = 4), underwent a single breathhold spiral CT (5 mm collision, 5 mm)/s increme...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章
doi：10.1016/s0169-2607(98)00053-4
更新日期：1998-08-01 00:00:00
abstract：:A highly optimized software for the kinetic analysis of complex chemical models is presented. The program is applied to the analysis of a vectorial biochemical reaction, where many species are linked by multiple equilibria of any order. The reaction stimulates the Ca2(+)-transport-linked ATPase reaction taking place i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90018-5
更新日期：1990-09-01 00:00:00
abstract：:In this paper, a new method for automatic sleep stage classification based on time-frequency image (TFI) of electroencephalogram (EEG) signals is proposed. Automatic classification of sleep stages is an important part for diagnosis and treatment of sleep disorders. The smoothed pseudo Wigner-Ville distribution (SPWVD)...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.07.006
更新日期：2013-12-01 00:00:00
