Receptor specificity defines algogenic properties of propofol and fospropofol.

abstract：BACKGROUND:Even though current perception threshold (CPT) has been used for evaluating the effectiveness of sensory block in patients before surgery, its reliability under controlled conditions has not been investigated. Two independent investigations were performed. The primary objective of the first study was to dete...

journal_title：Anesthesia and analgesia

authors： Gaudreault F,Drolet P,Fallaha M,Varin F

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:In this study, we tested the validity of the bispectral index (BIS) monitor during conscious and deep sedation of children by comparing it with the University of Michigan Sedation Scale (UMSS), a validated observational pediatric sedation scale. Eighty-six children <12 yr of age were enrolled in this observa...

journal_title：Anesthesia and analgesia

authors： McDermott NB,VanSickle T,Motas D,Friesen RH

更新日期：2003-07-01 00:00:00

abstract：UNLABELLED:We evaluated, by using a before-and-after study, the influence of leukoreduction by filtration on postoperative infections and adverse outcomes in patients undergoing elective major aortic surgery. From January 1995 to October 2000, all patients who underwent elective abdominal aortic surgery were included i...

journal_title：Anesthesia and analgesia

authors： Baron JF,Gourdin M,Bertrand M,Mercadier A,Delort J,Kieffer E,Coriat P

更新日期：2002-03-01 00:00:00

abstract：:The ex utero intrapartum treatment (EXIT) procedure provides time to secure the airway of the fetus while utero-placental circulation supplies the fetus with oxygen. We report the anesthetic management of a fetus with a large neck mass during an EXIT procedure in which the confirmation of correct endotracheal intubati...

journal_title：Anesthesia and analgesia

authors： Eschertzhuber S,Keller C,Mitterschiffthaler G,Jochberger S,Kühbacher G

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Anesthesia information management systems (AIMSs) have been effectively used to improve quality in anesthesia care, and have enabled the development of mandatory quality assurance (QA) reporting systems for adverse events (AEs). While this approach has been shown to increase event reporting over time, the lo...

journal_title：Anesthesia and analgesia

authors： Wanderer JP,Gratch DM,Jacques PS,Rodriquez LI,Epstein RH

更新日期：2018-01-01 00:00:00

abstract：:Sufentanil is a potent opioid that occasionally has been associated with hypotension. The mechanism behind this hypotension is unclear. We hypothesized that sufentanil had a direct effect on vascular smooth muscle to cause vasodilation. Sufentanil was infused into the brachial artery of 10 young, healthy volunteers at...

journal_title：Anesthesia and analgesia

authors： Ebert TJ,Ficke DJ,Arain SR,Holtz MN,Shankar H

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Patients with chronic pain frequently suffer affective disorders, particularly anxiety and depression. Although clinical research on the relationship between pain and depressive symptoms has been done, it is not clear whether pain causes depression or depression exaggerates pain. To investigate the relation ...

journal_title：Anesthesia and analgesia

authors： Suzuki T,Amata M,Sakaue G,Nishimura S,Inoue T,Shibata M,Mashimo T

更新日期：2007-06-01 00:00:00

abstract：UNLABELLED:We investigated the effect of IV droperidol on the bispectral index (BIS) in conscious and propofol-sedated patients during spinal anesthesia. Thirty minutes after the induction of spinal anesthesia, 20 patients were given 2 mg of droperidol IV without administration of other sedatives (conscious group). Ano...

journal_title：Anesthesia and analgesia

authors： Nakayama M,Kanaya N,Ichinose H,Yamamoto S,Namiki A

更新日期：2003-03-01 00:00:00

abstract：UNLABELLED:The calcium channel blocker nifedipine has analgesic properties that are enhanced by nicotine. Although it is not known how this analgesic state might affect the awareness of anginal pain and impending myocardial infraction, recent studies have shown an increased mortality associated with the use of large do...

journal_title：Anesthesia and analgesia

authors： Hunt TE,Wu WH,Zbuzek VK

更新日期：1998-11-01 00:00:00

abstract：:To determine whether nalbuphine might replace fentanyl as the principal opioid for anesthesia during coronary artery bypass surgery, 20 patients undergoing myocardial revascularization were anesthetized with flunitrazepam and with a continuous infusion of either nalbuphine (an opioid agonist-antagonist) or fentanyl (a...

journal_title：Anesthesia and analgesia

authors： Weiss BM,Schmid ER,Gattiker RI

更新日期：1991-11-01 00:00:00

abstract：:Attempted pulmonary artery catheterization via the left internal jugular vein resulted in a misdiagnosis of pulmonary hypertension before transesophageal echocardiography revealed the catheter positioned in the ascending aorta. Inadvertent aortic cannulation through an unusual type of partial anomalous pulmonary venou...

journal_title：Anesthesia and analgesia

authors： Siegmueller C,Bell A,Mittal T,George S

更新日期：2008-01-01 00:00:00

abstract：IMPLICATIONS:Entrapment of a guidewire in the vena cava filter during central venous catheter placement is a newly recognized complication. Complex techniques have been described to free the guidewire. We describe a simple in situ technique that may free the guidewire without the application of complex techniques. ...

journal_title：Anesthesia and analgesia

authors： Munir MA,Chien SQ

更新日期：2002-08-01 00:00:00

abstract：UNLABELLED:In this prospective investigation, we evaluated the efficacy and accuracy of transcutaneous monitoring of CO2 (TC-CO2) in infants and children after cardiothoracic surgery. Cardiothoracic surgery patients whose ETCO2 and arterial CO2 values did not correlate (gradient > or = 5 mm Hg) during the first postope...

journal_title：Anesthesia and analgesia

authors： Tobias JD,Wilson WR Jr,Meyer DJ

更新日期：1999-03-01 00:00:00

abstract：UNLABELLED:Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been used to treat rheumatic and osteoarthritic pain and to reduce postoperative pain. Although other NSAIDs, such as indomethacin, reduce cerebral blood flow (CBF), the effect of flurbiprofen on CBF is unknown. In the present study, we investig...

journal_title：Anesthesia and analgesia

authors： Yoshitani K,Kawaguchi M,Tatsumi K,Sasaoka N,Kurumatani N,Furuya H

更新日期：2004-02-01 00:00:00

abstract：:The traditional tests that have been used for the past 30 yr to determine plasma cholinesterase phenotype--measurement of esterase activity with a variety of substrates, dibucaine inhibition, fluoride inhibition, and Ro2-0683 inhibition--are inadequate for identifying some variants of this enzyme and leave many cases ...

journal_title：Anesthesia and analgesia

authors： Pantuck EJ

更新日期：1993-08-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to investigate whether propofol protects rat hepatocyte suspensions against an oxidant attack by a free radical generator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). Rat hepatocyte suspensions (2 x 10(6) cells/mL) were prepared using Seglen's collagenase perfusion tec...

journal_title：Anesthesia and analgesia

authors： Navapurkar VU,Skepper JN,Jones JG,Menon DK

更新日期：1998-11-01 00:00:00

abstract：:Tracheal temperature--the temperature of the tracheal wall--is believed to reflect the core temperature. The trachea reacts quickly to temperature changes because it is surrounded by various large arteries and veins. Using the blood temperature from the cardiopulmonary bypass (CPB) and the jugular vein temperature as ...

journal_title：Anesthesia and analgesia

authors： Yamakage M,Kawana S,Watanabe H,Namiki A

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:We evaluated the interaction of dopamine-proxymetacaine and dopamine- oxybuprocaine antinociception using isobolograms. METHODS:This experiment uses subcutaneous drug (proxymetacaine, oxybuprocaine, and dopamine) injections under the skin of the rat's back, thus simulating infiltration blocks. The dose-rela...

journal_title：Anesthesia and analgesia

authors： Chen YW,Chiu CC,Lin HT,Wang JJ,Hung CH

更新日期：2018-05-01 00:00:00

abstract：:Lumbar cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, which are used as indicators of central nervous system serotonergic neuronal activity, were significantly higher in 67 patients with chronic pain and in 32 patients with acute pain (23.6 +/- 3.3 and 23.1 +/- 3.8, respectively) than in 30 patients (8.8 +/...

journal_title：Anesthesia and analgesia

authors： Ghia JN,Mueller RA,Duncan GH,Scott DS,Mao W

更新日期：1981-12-01 00:00:00

abstract：:The hemodynamic effects of esmolol were studied in 40 patients scheduled for elective coronary artery surgery to determine whether the administration of esmolol in chronically beta-blocked patients would result in additional attenuation of sympathetically mediated hemodynamic stress responses to noxious stimuli. Patie...

journal_title：Anesthesia and analgesia

authors： de Bruijn NP,Croughwell N,Reves JG

更新日期：1987-02-01 00:00:00

abstract：:Many in vitro effects of volatile anesthetics are known, but the mechanisms of action are still under debate. Because suppression of sensory perception is one of the major goals of general anesthesia, we studied the effects of isoflurane on the processing of somatosensory information in anesthetized rats. Local iontop...

journal_title：Anesthesia and analgesia

authors： Vahle-Hinz C,Detsch O,Siemers M,Kochs E,Bromm B

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:The status of neuropathic pain alters the responsiveness to formalin injection in rats. However, the mechanism by which this alteration occurs is unknown. METHODS:We used immunocytochemistry to examine the expression of brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP) in t...

journal_title：Anesthesia and analgesia

authors： Kaku R,Yokoyama M,Kobayashi H,Matsuoka Y,Sato T,Mizobuchi S,Itano Y,Morita K

更新日期：2007-04-01 00:00:00

abstract：UNLABELLED:For adequate and safe use of high-frequency jet ventilation (HFJV), reliable monitoring of the PCO2 status and course is necessary. Because of improved handling and performance, recently available transcutaneous PCO2 monitoring devices such as MicroGas 7650 (Kontron Instruments Medical Sensors, Basel, Switze...

journal_title：Anesthesia and analgesia

authors： Biro P,Eyrich G,Rohling RG

更新日期：1998-07-01 00:00:00

abstract：UNLABELLED:Sevoflurane (SEVO) provides faster emergence than isoflurane (ISO). This advantage is thought to magnify with increased duration of exposure. In addition, SEVO has several of the characteristics of an ideal neuroanesthetic. We designed a prospective, randomized, double-blinded study to compare the recovery p...

journal_title：Anesthesia and analgesia

authors： Gauthier A,Girard F,Boudreault D,Ruel M,Todorov A

更新日期：2002-11-01 00:00:00

abstract：:Our aim was to determine how isoflurane modified crossbridge (CB) number and kinetics in airway smooth muscle (ASM) and to compare its effects in Fisher and Lewis rats, two strains with differences in airway responsiveness. The effects of isoflurane (2 MAC) on isotonic and isometric contractility in tracheal ASM strip...

journal_title：Anesthesia and analgesia

authors： Duracher C,Blanc FX,Gueugniaud PY,David JS,Riou B,Lecarpentier Y,Coirault C

更新日期：2005-07-01 00:00:00

abstract：UNLABELLED:We studied the effects of spinal cord stimulation (SCS) on postherpetic neuralgia (PHN). Data of 28 patients were prospectively investigated over a median period of 29 (quartiles 9--39) mo. In addition, four patients with acute herpes zoster (HZ) pain were studied simultaneously. After intractable pain for m...

journal_title：Anesthesia and analgesia

authors： Harke H,Gretenkort P,Ladleif HU,Koester P,Rahman S

更新日期：2002-03-01 00:00:00

abstract：:The insertion of implantable cardioverter/defibrillators (ICD) requires induction of repeated episodes of ventricular fibrillation (VF). The neuropsychological repercussions associated with repeated inducement of hypotension and cerebral ischemia are unknown. In this prospective clinical trial, 1 day prior to ICD asse...

journal_title：Anesthesia and analgesia

authors： Murkin JM,Baird DL,Martzke JS,Yee R

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Admission hypocalcemia predicts both massive transfusion and mortality in severely injured patients. However, the effect of calcium derangements during resuscitation remains unexplored. We hypothesize that any hypocalcemia or hypercalcemia (either primary or from overcorrection) in the first 24 hours after s...

journal_title：Anesthesia and analgesia

authors： MacKay EJ,Stubna MD,Holena DN,Reilly PM,Seamon MJ,Smith BP,Kaplan LJ,Cannon JW

更新日期：2017-09-01 00:00:00

abstract：UNLABELLED:Intrathecal (IT) sufentanil provides effective analgesia for extracorporeal shock wave lithotripsy. However, the optimal dose of sufentanil has not been established. We designed a prospective, randomized, double-blinded study to determine the optimal dose of IT sufentanil. Sixty men were randomized to receiv...

journal_title：Anesthesia and analgesia

authors： Lau WC,Green CR,Faerber GJ,Tait AR,Golembiewski JA

更新日期：1999-10-01 00:00:00

abstract：UNLABELLED:Endothelial dysfunction and platelet activation with thromboxane release may contribute to spasm or alterations in internal mammary artery (IMA) graft flow during coronary artery surgery. Clevidipine, an ultrashort-acting dihydropyridine calcium channel blocker, is undergoing clinical development, but there ...

journal_title：Anesthesia and analgesia

authors： Huraux C,Makita T,Szlam F,Nordlander M,Levy JH

更新日期：1997-11-01 00:00:00