Abstract：
:We tested whether the ratio of alveolar dead space to alveolar tidal volume (VD(alv)/VT(alv)) can detect states of low pulmonary blood flow (PBF) in a non-invasive way. Fifteen patients undergoing cardiovascular surgeries with cardiopulmonary bypass (CPB) were studied. CPB is a technique that excludes the lungs from the general circulation. The weaning of CPB is a model that manipulates PBF in vivo because each time blood flow through the CPB decreases, expected PBF (ePBF) increases. Patients were liberated from CPB in steps of 20 % every 2' starting from 100 % CPB (very low ePBF) to 0 % CPB (100 % ePBF). During constant ventilation, volumetric capnograms were recorded and Bohr's dead space ratio (VD(Bohr)/VT), VD(alv)/VT(alv) and the ratio of airway dead space to tidal volume (VD(aw)/VT) were calculated. Before CPB, VD(Bohr)/VT was 0.36 ± 0.05, VD(aw)/VT 0.21 ± 0.04 and VD(alv)/VT(alv) 0.18 ± 0.06 (mean ± SD). During weaning from CPB, VD(aw)/VT remained unchanged while VD(Bohr)/VT and VD(alv)/VT(alv) decreased with increasing ePBF. At CPB of 80, 60, 40 and 20 % VD(Bohr)/VT was 0.64 ± 0.06, 0.55 ± 0.06, 0.47 ± 0.05 and 0.40 ± 0.04, respectively; p < 0.001 and VD(alv)/VT(alv) 0.53 ± 0.07, 0.40 ± 0.07, 0.29 ± 0.06 and 0.25 ± 0.04, respectively; p < 0.001). After CPB, VD(Bohr)/VT and VD(alv)/VT(alv) reached values similar to baseline (0.37 ± 0.04 and 0.19 ± 0.06, respectively). At constant ventilation the alveolar component of VD(Bohr)/VT increased in proportion to the deficit in lung perfusion.
journal_name
J Clin Monit Computjournal_title
Journal of clinical monitoring and computingauthors
Tusman G,Suarez-Sipmann F,Paez G,Alvarez J,Bohm SHdoi
10.1007/s10877-012-9358-9subject
Has Abstractpub_date
2012-06-01 00:00:00pages
183-90issue
3eissn
1387-1307issn
1573-2614journal_volume
26pub_type
杂志文章abstract：:Heart failure is the main cause of poor outcome following open heart surgery and experimental studies have demonstrated that glucose-insulin-potassium (GIK) infusion exerts cardioprotective effects by reducing myocardial ischemia-reperfusion injuries. This randomized controlled trial was designed to assess the effects...
journal_title：Journal of clinical monitoring and computing
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abstract：:While the effects of phenylephrine (PE) and ephedrine (E) on cerebral oxygen saturation (rScO2) already has been studied, the effect on paraspinal oxygen saturation (rSpsO2) is still unexplored. This study aims to assess the effect of PE and E on rScO2 and rSpsO2, measured with near-infrared spectroscopy. A randomized...
journal_title：Journal of clinical monitoring and computing
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abstract：:Excessive pressures exerted on the tongue during intubation may be associated with serious complications and may make intubation more difficult. The aim of this study was to evaluate five different intubating devices in the hands of experienced anaesthetists during simulated conditions of reduced cervical spine mobili...
journal_title：Journal of clinical monitoring and computing
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doi：10.1007/s10877-017-0095-y
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abstract：:The goal of this study was to evaluate the risk factors associated with positioning-related SSEP changes (PRSC). The study investigated the association between 18 plausible risk factors and the occurrence of intraoperative PRSC. Risk factors investigated included demographic variables, comorbidities, and procedure rel...
journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
doi：10.1007/s10877-018-0148-x
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journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,多中心研究
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更新日期：2008-04-01 00:00:00
abstract：:The eye lens is one of the most sensitive organs for radiation injury and exposure might lead to radiation induced cataract. Eye lens dosimetry in anesthesiology has been published in few clinical trials and an active debate about the causality of radiation induced cataract is still ongoing. Recently, the Internationa...
journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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doi：10.1007/s10877-005-1158-z
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,评审
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journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章,评审
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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doi：10.1007/s10877-005-3463-y
更新日期：2005-10-01 00:00:00
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journal_title：Journal of clinical monitoring and computing
pub_type： 杂志文章
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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journal_title：Journal of clinical monitoring and computing
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更新日期：2013-10-01 00:00:00
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journal_title：Journal of clinical monitoring and computing
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abstract：:Transesophageal echocardiography of the spine has been difficult to perform, and high-quality images have been difficult to obtain with earlier available technology. New capabilities in hardware and software reconstruction may allow more reliable clinical data to be obtained. We describe an initial successful attempt ...
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abstract：:Microvascular function may be modulated by various anesthetics. Desflurane and propofol anesthesia have different effects on microvascular function. However, there are few reports on the effects of sevoflurane and desflurane on microvascular function during cardiac surgery. We compared the effects of sevoflurane and d...
journal_title：Journal of clinical monitoring and computing
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