Abstract:
:While the effects of phenylephrine (PE) and ephedrine (E) on cerebral oxygen saturation (rScO2) already has been studied, the effect on paraspinal oxygen saturation (rSpsO2) is still unexplored. This study aims to assess the effect of PE and E on rScO2 and rSpsO2, measured with near-infrared spectroscopy. A randomized 4-treatment cross-over trial was designed in 28 patients under BIS-titrated anaesthesia with sevoflurane. If MAP decreased more than 20% from baseline, incremental doses of PE and/or E were given according to the randomization (group I: E-PE-E, group II: PE-E-PE, group III: E-E-E, group IV: PE-PE-PE). rScO2 and rSpsO2 on T3-T4, T9-T10 and L1-L2 were recorded. Differences in rSO2 (post-pretreatment) within each group were analyzed with paired Student's t test. Differences in effects of PE and E on rScO2 and rSpsO2 were analyzed with linear mixed-modelling. Following PE administration, rScO2 decreased significantly (- 2.7% ± 3.5), while it remained stable following E (- 0.6% ± 3.6). Contrastingly, rSpsO2 at T3-T4, T9-T10 and L1-L2 slightly increased following PE (0.4% ± 2.5, 0.7% ± 2.0 and - 0.1% ± 1.4, respectively), while it decreased after E administration (- 1.3% ± 3.4%, - 0.7% ± 2.6% and - 1.3% ± 2.7%, respectively). Compared to E, PE administration was associated with a significant decrease in rScO2 (- 2.1%, 95% CI [- 3.1%, - 1.2%], p < 0.001). In contrast, compared to PE, E was associated with a significant decrease in rSpsO2 at T3-T4, T9-T10 and L1-L2 (- 2.0%, 95% CI [- 2.8, - 1.1], p < 0.001; - 1.4%, 95% CI [- 2.4%, - 0.4%], p = 0.006; and - 1.5%, 95% CI [- 2.3%, - 0.8%], p < 0.001, respectively). An opposite effect on rScO2 and rSpsO2 was observed after bolus administration of PE and E.
journal_name
J Clin Monit Computjournal_title
Journal of clinical monitoring and computingauthors
Vanpeteghem CM,Bruneel BY,Lecoutere IM,De Hert SG,Moerman ATdoi
10.1007/s10877-019-00328-6subject
Has Abstractpub_date
2020-04-01 00:00:00pages
253-259issue
2eissn
1387-1307issn
1573-2614pii
10.1007/s10877-019-00328-6journal_volume
34pub_type
杂志文章abstract::Increasing process complexity in the pediatric intensive care unit (PICU) can lead to information overload resulting in missing pertinent information and potential errors during morning rounds. An efficient model using a novel electronic rounding tool was designed as part of a broader critical care decision support sy...
journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,评审
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journal_title:Journal of clinical monitoring and computing
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更新日期:2005-12-01 00:00:00
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journal_title:Journal of clinical monitoring and computing
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical monitoring and computing
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