Eight years of Legionnaires' disease transmission in travellers to a condominium complex in Las Vegas, Nevada.

Abstract:

:Travel is a risk factor for Legionnaires' disease. In 2008, two cases were reported in condominium guests where we investigated a 2001 outbreak. We reinvestigated to identify additional cases and determine whether ongoing transmission resulted from persistent colonization of potable water. Exposures were assessed by matched case-control analyses (2001) and case-series interviews (2008). We sampled potable water and other water sources. Isolates were compared using sequence-based typing. From 2001 to 2008, 35 cases were identified. Confirmed cases reported after the cluster in 2001-2002 were initially considered sporadic, but retrospective case-finding identified five additional cases. Cases were more likely than controls to stay in tower 2 of the condominium [matched odds ratio (mOR) 6·1, 95% confidence interval (CI) 1·6-22·9]; transmission was associated with showering duration (mOR 23·0, 95% CI 1·4-384). We characterized a clinical isolate as sequence type 35 (ST35) and detected ST35 in samples of tower 2's potable water in 2001, 2002, and 2008. This prolonged outbreak illustrates the importance of striving for permanent Legionella eradication from potable water.

journal_name

Epidemiol Infect

authors

Silk BJ,Moore MR,Bergtholdt M,Gorwitz RJ,Kozak NA,Tha MM,Brown EW,Winchester JL,Labus BJ,Rowley P,Middaugh JP,Fields BS,Hicks LA

doi

10.1017/S0950268811002779

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1993-2002

issue

11

eissn

0950-2688

issn

1469-4409

pii

S0950268811002779

journal_volume

140

pub_type

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