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Osteoprotegerin (OPG) and TNF-related apoptosis-inducing ligand (TRAIL) levels in malignant and benign pericardial effusions.

Abstract：

OBJECTIVES:Osteoprotegerin (OPG) is a regulator of bone and vascular homeostasis and acts as a decoy receptor for proapoptotic TNF-related apoptosis-inducing ligand (TRAIL). DESIGN AND METHODS:We assessed pericardial and serum levels of OPG and TRAIL in pericardial effusions (PE) of malignant (mPE, n=24) or non-malignant (nPE, n=34) origin, and in pericardial fluid (PF, n=25) of coronary artery disease (CAD) patients by ELISA. RESULTS:OPG was at least 5 fold higher in PE or PF compared to serum, with a significantly higher ratio of pericardial to serum OPG in patients with mPE or nPE compared to PF (mPE vs. PF, p=0.011; nPE vs. PF, p<0.001). TRAIL was only detectable in mPE and PF. Logistic regression analysis revealed that a high ratio of pericardial to serum OPG and high TRAIL in PE were the best variable combination to predict malignancy of PE. CONCLUSIONS:Pericardial and systemic OPG or TRAIL are potential diagnostic tools to discriminate between malignant or benign PE.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Karatolios K,Pankuweit S,Goettsch C,Hofbauer LC,Timmesfeld N,Al-Fakhri N,Maisch B,Schoppet M

doi

10.1016/j.clinbiochem.2011.12.003

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

237-42

issue

3

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(11)02748-2

journal_volume

45

pub_type

杂志文章

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