Abstract：
:Extreme antigenic and genetic heterogeneity of serotype A foot-and-mouth disease virus (FMDV) population has resulted in change of vaccine strains in India twice in the last decade. In such a situation, complete characterization of the vaccine strains is imperative. With regard to the frequent outbreaks of this disease, FMDV field strains are also of interest. Therefore three vaccine strains and two field strains of type A FMDV from India were completely sequenced and the obtained sequences were subjected to sequence and phylogenetic analyses. Based on the complete coding region, all the Indian strains clustered in the Asia topotype and exhibited a more than 11% nt divergence from the other Asian strains. The 5'-UTR of some Indian strains revealed block deletions of 43 and 86 nt corresponding to the pseudoknot region. Amino acids S44 in VP2 and F164 in VP1 were found to be the exclusive signatures for the Asia topotype. The vaccine strains differed at 65 aa positions in the capsid region, 13 of them antigenically critical. Variability at such positions is likely to affect the antigenic profile of these strains. Complete genome sequences of the vaccine strains presented here could serve as the reference for any comparative genomics in future.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Mohapatra JK,Pawar SS,Tosh C,Subramaniam S,Palsamy R,Sanyal A,Hemadri D,Pattnaik Bdoi
10.4149/av_2011_04_349subject
Has Abstractpub_date
2011-01-01 00:00:00pages
349-52issue
4eissn
0001-723Xissn
1336-2305journal_volume
55pub_type
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