Abstract:
:S100P belongs to several members of the S100 family of calcium-binding proteins, associated with malignant phenotype. Altered levels of S100P expression have been described at different stages and types of cancer. Transcriptional regulation involves different pathways activated by glucocorticoids, growth factors and bone morphogenic factor via the corresponding receptors. Signals coming from these pathways appear to be transmitted through ERK1/2 (extracellular-signal regulated kinase) and mediated presumably by STAT, SMAD, NFkB transcription factors. The secreted form of S100P can bind to extracellular ligand-binding site of RAGE (receptor for advanced glycation end-products), and via activation of ERK/MAPK pathway can influence gene expression, cell proliferation and survival. In addition, S100P interacts and modulates the activity of several targets with multiple binding modes and simultaneous coordination of further target proteins in larger multiprotein complexes, e.g. scaffolding proteins -IQGAP1 and ezrin, known to promote and regulate signal transduction pathways. The majority of S100P binding partners are proteins involved in cytoskeletal dynamics, and their physical interactions with S100P lead to defects in cellular morphogenesis and tissue disruption, the acquisition of uncontrolled migratory and invasive features. Finally, the evidence for S100P role in cancer metastasis opens a new direction for the future research efforts.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Tóthová V,Gibadulinová Adoi
10.4149/av_2013_02_238subject
Has Abstractpub_date
2013-01-01 00:00:00pages
238-46issue
2eissn
0001-723Xissn
1336-2305journal_volume
57pub_type
杂志文章,评审相关文献
ACTA VIROLOGICA文献大全abstract::Herpes zoster (HZ) is a neurocutaneous disease caused by Varicella-zoster virus (VZV) as a consequence of declined cell-mediated immunity, immune suppression and immunodeficiency. As reactivation of JC polyomavirus (JCPyV) might be linked with immunodeficiency or immunosuppressive therapy, the relationship between HZ ...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Molecular analysis of histological hallmarks (neurofibrillary tangles, neuritic plaques, neuropil threads and dystrophic neurites) of Alzheimer diseased brain tissues showed that these lesions contain paired helical filaments. Their major constituent is microtubule associated protein tau that is in an abnormally hyper...
journal_title:Acta virologica
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::Alzheimer's disease (AD) the most common form of dementia is characterized by cognitive decline and progressive loss of neurons in the central nervous system. Despite huge scientific progress, there are only few animal models that recapitulate at least majority of the AD pathology and related symptomatology. Therefore...
journal_title:Acta virologica
pub_type: 杂志文章,评审
doi:10.4149/av_2017_01_13
更新日期:2017-01-01 00:00:00
abstract::Nucleoprotein (NP) complexes constituting the material of the postmicrosomal sediment (POMS) and its three basic components (A, B, C) (Ríman and Sulová, 1997a), harboring an extrachromosomal DNA closely related to AMV DNA were found to possess DNA- and RNA-synthesizing activities (SAs) reflecting the ability of this m...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1997-08-01 00:00:00
abstract::For the quantitative assay of selected togaviruses, suspensions of BHK cells were inoculated with virus and grown in spinner cultures. At intervals, dependent on the growth characteristics of the viruses, about 10(3) cells were centrifuged on to microscope slides and then stained with fluorescent antibody. For rapid d...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::Biological properties of antigens of whole cells of C. burnetii in phase I (WCI), their residue (CMR) and extract (CME) obtained by extraction of C. burnetti with chloroform/methanol mixture were subjected to a comparative study. It was shown that CME is able to react specifically with sera containing antibodies again...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Sensitivity and specificity of a modified agar gel immuno-diffusion (AGID) test for the diagnosis of enzootic bovine leukosis was compared in 609 sera using the standard method, the modified test, and ELISA. The modifications concerned the composition of agar gel (1.8% Bacto-agar Difco), addition of polyethylene glyco...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Alfalfa mosaic virus (AMV) was found to be transmitted through seeds of Nicandra physaloids L. The average seed transmission rate of the AMV isolates T6, LMBG-4 and ST amounted to 23, 4 and 0 per cent, repectively. In the cytoplasm of parenchyma cells of embryo cotyledons of seeds from plants infected with the T6 isol...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::2-0-hexadecyl-glycero-3-phosphocholine (GPC) 1 mmol/l solution reduced the infectivity of red clover mottle virus (RCMV) by over 90%. The binding of GPC molecules to RCMV particles was investigated with 1H-nmr spectroscopy, which showed a striking interaction between virus particles and GPC molecules. In 10 mmol/l GPC...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::The successive injection of non-immunomodulating doses of Tahyna virus (100 LD50) and non-immunomodulating doses of immunomodulating drugs, such as purified staphylococcal toxoid or glucosaminylmuramyldipeptide (Likopid), to mice were accompanied by a decrease in the IgM plaque-forming cell response to sheep red blood...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Viraemia was studied in adult Clethrionomys glareolus subcutaneously infected with 12 strains of tick-borne encephalitis (TBE) virus isolated in western and eastern foci of TBE. Nine strains caused viraemia regularly or irregularly, reaching titres higher than the threshold level of TBE virus infectivity for its vecto...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents a serious neural infection of humans in Europe and Asia. The main reservoir hosts of TBEV are ticks, rodents and insectivores, but domestic animals may also be infected with the virus. This review summarizes what is kno...
journal_title:Acta virologica
pub_type: 杂志文章
doi:10.4149/av_2020_212
更新日期:2020-01-01 00:00:00
abstract::The chemical nature of BK virus receptors on human erythrocytes was investigated. Glycosidases, KIO4, proteases, phospholipases and other substances acting specifically on different structures of plasma membranes were used to ascertain the role of surface cell components in the interaction with BK virus. The results o...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::39K protein was proven to be the most notable hyperphosphorylated protein of Bombyx mori nucleopolyhedrovirus (BmNPV), since its amino acid 136 has the highest phosphorylation ratio (16.683) among all of BmNPV phosphorylated proteins (Shobahah et al., 2017). Therefore, we inserted positive (mimicking phosphorylation) ...
journal_title:Acta virologica
pub_type: 杂志文章
doi:10.4149/av_2019_414
更新日期:2019-01-01 00:00:00
abstract::Peanut stripe virus (PStV) is one of the most common viruses infecting peanut that causes great economic losses every year. The 3ʹ-terminal 1082 bp of 74 PStV isolates collected from 12 districts of Shandong province, China were sequenced. Their coat protein (CP) genes were 864 bp in length and shared identities of 98...
journal_title:Acta virologica
pub_type: 杂志文章
doi:10.4149/av_2011_02_123
更新日期:2011-01-01 00:00:00
abstract::Nonlethal infection was induced in laboratory mice with sublethal doses of rabies strains isolated from small wild rodents. Three types of nonlethal infecion were observed: persistent--with virus irregularly reisolable for at least 56 days after inoculation: latent--with negative virus reisolation but presence of infe...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::In vivo phagocytosis activity of macrophages (PAM) was temporarily suppressed in mice by application of a suspension of microscopic from particles. As demonstrated, a reversible block of 70% of PAM was accompanied by a marked increase of the lethality during the acute tick-borne encephalitis (TBE) virus infection. Asy...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract::Phages are excellent models for studying the mechanism of DNA replication in prokaryotes. Identification of phage proteins involved in phage DNA replication is the first prerequisite for elucidation of the phage replication module. We focused on replication proteins gp41 (a putative helicase from SF2 superfamily), gp4...
journal_title:Acta virologica
pub_type: 杂志文章
doi:10.4149/av_2014_02_152
更新日期:2014-01-01 00:00:00
abstract::Twenty three strains of simian viruses isolated from nasopharyngeal swabs and respiratory tissues of cynomolgus monkeys showing mild symptoms of respiratory disorders were classified into three groups by their biological, serological and morphological characteristics. Thirteen strains classified as group 1 were judged...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract::The nucleotide (nt) sequences of the envelope (E) gene of 4 Japanese encephalitis virus (JEV) isolates from Korea (K82PO1, K87P39, K91P55 and K94PO5) were determined and the deduced amino acid (aa) sequences were compared within themselves and with the published sequences of 16 other JEV strains originating from other...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::An atypical mild isolate HV5 of Grapevine fanleaf virus (GFLV) was found in a South Moravian viticulture region in Czech Republic. Partial sequence of its RNA2 was determined and compared with available sequences of typical GFLV isolates. Two genomic regions, namely a 814 nt-long one spanning the movement protein (MP)...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::An in situ assay for detecting DNA-binding proteins in herpes simplex virus type 1 (HSV-1)-infected cells is described. Seventeen HSV-induced DNA-binding species were visible with nicked, double-stranded DNA as a substrate, while fourteen virus-induced DNA-binding fractions were present in gels containing nuclease-tre...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::Cell-mediated reactions in measles cases, in direct contacts and healthy children were tested. Indices of phytohaemagglutinin-stimulated blastic transformation and leukocyte migration inhibition were evaluated. Positive reactions were found in the first and second weeks after manifestation of clinical symptoms. The ap...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1980-03-01 00:00:00
abstract::A mathematical model of the pathogenesis of experimental Mengo virus infection in mice has been developed and fitted using kinetic data of both virus multiplication in different organs and mortality. The behaviour of the model proved to be bistable. In contrast to the widely accepted hypothesis that an acutely virus-i...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract:UNLABELLED:Influenza A (H1N1) virus is an important pathogen that can be transmitted in the enzootic cycle involved in influenza epidemics. In this study, we analyzed natural selection on the 260 sequences of subtype 1 hemagglutinin (HA1) gene of H1N1 viruses isolated from humans and swine in Asia. Nonsynonymous and sy...
journal_title:Acta virologica
pub_type: 杂志文章
doi:10.4149/av_2010_02_113
更新日期:2010-01-01 00:00:00
abstract::Genetic composition and biological properties of influenza virus recombinants A/PR/8/34 (H1N1) and A/Greifswald/6/74 (H3N2) were analysed. The haemagglutinin (HA) gene of the strain A/PR/8/34 was shown an important part of the gene complex determining the virulence for mice, the yield of HA and the plaque forming capa...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Hepatitis C virus (HCV) infection, with an estimated 170 million carriers worldwide, remains a major cause of chronic liver disease. Current anti-HCV treatments have significant side effects and have met with only partial success. Therefore, a more effective therapeutic modality for HCV infection is needed. The stabil...
journal_title:Acta virologica
pub_type: 杂志文章,评审
doi:10.4149/av_2014_04_301
更新日期:2014-01-01 00:00:00
abstract::Chromosomal DNAs isolated from eight individuals from the Slovak population and from lymphoblastoid Namalwa cells were analyzed for the presence of genes coding for three subvariants of human interferon-alpha 2 (IFN-alpha 2), namely a, b, and c. The respective genes are regarded allelic, because they differ in the cod...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::A resistant influenza virus has been obtained during successive passages of influenza A virus in 10 to 11-day-old chick embryos (CE) in the presence of 2-(1'-amino-ethyl)-bicyclo(2.2.1) heptane chlorohydrate possessing a high antiviral activity. The virus resistance to the inhibitor was not lost after one passage in t...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::In this study, DNA vaccines consisting of vector IRES-gD expressing Herpes simplex virus 1 (HSV-1) glycoprotein D (gD) and vector IRES-gD-IL-2 coexpressing HSV-1 gD and interleukin-2 (IL-2), respectively, were constructed. After intramuscular inoculation, both vaccines induced in BALB/c mice antibodies as assayed by E...
journal_title:Acta virologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00