Abstract：
:Hepatitis C virus (HCV) infection, with an estimated 170 million carriers worldwide, remains a major cause of chronic liver disease. Current anti-HCV treatments have significant side effects and have met with only partial success. Therefore, a more effective therapeutic modality for HCV infection is needed. The stability and propagation of HCV is dependent on the interaction between its genome and a highly abundant liver microRNA (miRNA), known as microRNA-122 (miR-122). As a conserved host factor that would not be expected to evolve resistance mutations, miR-122 makes an attractive antiviral target. In this review we will discuss how targeting miR-122, using antisense oligonucleotides (ASOs), can be a new anti-HCV treatment.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Motavaf M,Safari S,Alavian SMdoi
10.4149/av_2014_04_301subject
Has Abstractpub_date
2014-01-01 00:00:00pages
301-8issue
4eissn
0001-723Xissn
1336-2305journal_volume
58pub_type
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