Abstract：
:Molecular analysis of histological hallmarks (neurofibrillary tangles, neuritic plaques, neuropil threads and dystrophic neurites) of Alzheimer diseased brain tissues showed that these lesions contain paired helical filaments. Their major constituent is microtubule associated protein tau that is in an abnormally hyperphosphorylated and truncated state. These diseased forms of tau protein are unable to promote full microtubule assembly. Understanding of the molecular basis of the processes leading to the modifications of tau proteins and paired helical filament formation will form a firm step toward rational drug development and the cure of the Alzheimer's disease.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Novák Msubject
Has Abstractpub_date
1994-06-01 00:00:00pages
173-89issue
3eissn
0001-723Xissn
1336-2305journal_volume
38pub_type
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