Abstract：
:In this report, we have investigated the role of copper (Cu) and zinc (Zn) in oxidative stress induced by cadmium (Cd) in C6 cells. Cells were exposed to 20 μM Cd, 500 μM Cu, and 450 μM Zn for 24 h. Then, toxic effects, cellular metals levels, oxidative stress parameters, cell death, as well as DNA damage were evaluated. Cd induced an increase in cellular Cd, Cu, and Zn levels. This results not only in the inhibition of GSH-Px, GRase, CAT, and SOD activities but also in ROS overproduction, oxidative damage, and apoptotic cell death not related to Cu and Zn mechanisms. The thiol groups and GSH levels decreased, whereas the lipid peroxidation and DNA damage increased. The toxicity of Zn results from the imbalance between the inhibition of antioxidant activities and the induction of MT synthesis. The increase in Cu and Zn levels could be explained by the disruption of specific transporter activities, Cd interference with signaling pathways, and metal displacement. Our results suggest that the alteration of Cu and Zn homeostasis is involved in the oxidative stress induced by Cd.
journal_name
Biol Trace Elem Resjournal_title
Biological trace element researchauthors
Nzengue Y,Steiman R,Rachidi W,Favier A,Guiraud Pdoi
10.1007/s12011-011-9265-9subject
Has Abstractpub_date
2012-06-01 00:00:00pages
410-9issue
3eissn
0163-4984issn
1559-0720journal_volume
146pub_type
杂志文章abstract：:This study was undertaken to evaluate the impact of Plan Más Vida (PMV) on the micronutrient nutritional condition of children aged 1 to 6 years 1 year after PMV implementation. The food program was intended for low-income families from the province of Buenos Aires, Argentina and provided supplementary diets. A prospe...
journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
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journal_title：Biological trace element research
pub_type： 杂志文章
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