Abstract：
BACKGROUND AND AIMS:Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AGEs, RAGE and sRAGE in patients with type 2 diabetes (T2D). METHODS:RAGE gene expression was determined by real-time PCR in 50 patients with T2D (27 men, mean age 52 ± 7.7 years) and 50 age-matched controls without T2D. Serum AGEs and sRAGEs were assayed by enzyme-linked immunosorbent assay (ELISA). RESULTS:Serum level of AGEs was increased in patients with T2D (10.35 ± 2.27 μg/mL vs.7.69 ± 0.56 μg/mL, p <0.05). sRAGE was decreased in patients with T2D (573.6 ± 172.5 pg/mL vs. 603.4 ± 120.8 pg/mL p <0.01). RAGE gene expression was higher in T2D than in controls (p <0.01). There was an association between monocyte RAGE and serum levels of AGEs in both T2D patients (r = 0.29, p = 0.03) and controls (r = 0.31, p = 0.02). Serum AGEs correlated with homeostasis model assessment of insulin resistance (HOMA-IR) in both patients with T2D (r = 0.322, p = 0.004) and controls (r = 0.281, p = 0.003). CONCLUSIONS:Serum AGEs and monocyte RAGE expression are increased in patients with T2D, whereas serum sRAGE is decreased. Pharmacological intervention on serum AGEs and sRAGE may be a potential therapy for diabetes.
journal_name
Arch Med Resjournal_title
Archives of medical researchauthors
Su XD,Li SS,Tian YQ,Zhang ZY,Zhang GZ,Wang LXdoi
10.1016/j.arcmed.2011.11.001subject
Has Abstractpub_date
2011-10-01 00:00:00pages
596-601issue
7eissn
0188-4409issn
1873-5487pii
S0188-4409(11)00216-5journal_volume
42pub_type
杂志文章abstract：BACKGROUND:The aim of this study was to determine concentrations of tumor necrosis factor-alpha (TNF-alpha) in normal, painful, and asymptomatic human dental pulps. METHODS:Pulps were obtained from three groups of teeth, including healthy teeth, asymptomatic teeth with caries and/or large restoration, and symptomatic ...
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更新日期：1996-07-01 00:00:00
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更新日期：1995-10-01 00:00:00
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更新日期：2001-11-01 00:00:00
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更新日期：2013-05-01 00:00:00
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更新日期：2017-04-01 00:00:00
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journal_title：Archives of medical research
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更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The present study was designed to examine whether resveratrol, a potent antioxidant, protects against renal ischemia-reperfusion (I/R) injury. METHODS:Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 6 h of reperfusion. Resveratrol (RVT, 30 m...
journal_title：Archives of medical research
pub_type： 杂志文章
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更新日期：2006-10-01 00:00:00
