[Pharmacologic bases of chemotherapy of brain tumors in children].

Abstract:

:In terms of pharmacology, drug delivery is an important obstacle in the development of brain tumor chemotherapy. The blood-brain barrier limits the drug penetration in normal brain tissue around the tumor and at distant potential metastatic sites. In the tumor, the altered blood-brain barrier, ie blood-tumor barrier, decreases the drug entry in malignant cells. The knowledge of the blood-brain barrier physiology and the definition of the laws that govern the drug delivery to the central nervous system allow the development of new strategies to increase drug delivery to the tumor. In pediatric oncology, the more appropriate methods are the use of anticancer agents that easily cross the blood-brain barrier and the development of high-dose systemic chemotherapy regimens with or without bone marrow rescue.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Vassal G

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

699-713

issue

7

eissn

0007-4551

issn

1769-6917

journal_volume

77

pub_type

杂志文章
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  • [Sarcomas of soft tissue in the adult. Therapeutical indications].

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    journal_title:Bulletin du cancer

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  • [Pharmacology of platinum analogs-taxanes interactions].

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    doi:

    authors: Boisdron-Celle M,Gamelin E

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    authors: Galiano M,Rozet F,Cathelineau X,Barret E,Vallancien G

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  • [Epidemiology of HIV-associated malignancies].

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    authors: Launay O,Guillevin L

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    pub_type: 杂志文章,评审

    doi:

    authors: Maubant S,Staedel C,Gauduchon P

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  • [Frequency of cancer at older ages].

    abstract::The dependency between the risk of death and age is analysed, and the contribution of cancer to the overall risk of death is evaluated as a function of age. The frequency of the different cancer sites is described in different age groups. Lastly cancer mortality trends are presented by age. The risk of death from canc...

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    doi:10.1684/bdc.2007.0531

    authors: Hill C,Doyon F

    更新日期:2008-05-28 00:00:00

  • [Hypoxia and angiogenesis].

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    doi:

    authors: Simon JM

    更新日期:2007-07-01 00:00:00

  • [The value of MRI in the diagnosis of joint involvement in malignant primitive tumors of the knee].

    abstract:INTRODUCTION:Surgical treatment of malignant primitive tumors of bone needs a precise preoperative assessment of tumor local extension. Joint involvement (JI) represents the most important finding to determine, for the choice of surgical procedure (intra- or extra-articular resection). OBJECTIVE:To determine the value...

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  • [Marital communication and depressive symptoms in couples in which the woman has cancer of the breast].

    abstract::If doctor-patient communication is a frequent subject of research, couples communication where one partner has cancer is quite recent. Some studies deal with couples communication, but from an anecdotic perspective, without any operational measure. The aim of this paper is to study couples' communication frequency and...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Normand J,Lasry JC,Margolese RG,Perry JC,Fleiszer D

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  • [Study of mdm2 gene amplification in primary breast tumors].

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    doi:

    authors: Fontana X,Ferrari P,Abbes M,Monticelli J,Namer M,Bussière F

    更新日期:1994-07-01 00:00:00

  • [Cognitive impairments and breast cancer: a critical review of the literature].

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  • [Towards a new standard in cytoreductive surgery for advanced ovarian cancer].

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  • [Qualitative and collaborative research with cancer patients. Experience narratives of treatments for peritoneal carcinomatosis].

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  • [Use of maintenance therapy and complete discontinuation for therapeutic management of non-resectable metastatic colorectal cancer].

    abstract::Management of unresectable metastatic colorectal cancer dramatically changed over the past 20 years. News standards of care combine cytotoxic drugs like fluoropyrimidines, irinotecan and oxaliplatin, with targeted therapies such as anti-EGFR monoclonal antibodies and anti-angiogenic agents. Survival benefit results fr...

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    doi:10.1684/bdc.2014.1984

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  • [Value of mono-antibiotic therapy using piperacillin associated with sulbactam and possibly followed by vancomycin in febrile neutropenia in solid tumors].

    abstract::We evaluated the efficacy and safety of a monotherapy by piperacillin and sulbactam potentially associated to vancomycin as an empiric antimicrobial therapy in febrile neutropenic patients treated with nephrotoxic chemotherapy for solid tumors. Twenty-three patients were treated during 32 episodes with piperacillin 4 ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Abs L,Kattan J,Culine S,Bekradda M,Farhat F,Droz JP

    更新日期:1994-10-01 00:00:00

  • [Osteonecrosis of the jaw and bisphophonates in oncology].

    abstract::Bisphosphonates are potent osteoclastic inhibitors that are indicated in the prevention of bone complications. They could also be of interest in the prevention of bone metastases. Several recent international publications have highlighted the onset of osteonecrosis of the jaw (ONJ) in patients treated with bisphosphon...

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    更新日期:2008-04-01 00:00:00

  • [Axillary lymphadenectomy prepared by fat aspiration versus functional axillary lymphadenectomy: preliminary results of a randomized prospective study].

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Giard S,Laurent JC,Dron AM,Lefebvre D

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  • [Melanomas of the female genital tract: state of the art].

    abstract::Melanoma of the female genital tract is a rare location (less than 2% of melanomas all sites combined). These cancers have a very poor prognosis, due to the delay in diagnosis. Vulvar location is about 1% of melanomas then the vaginal location, uterine and ovarian. There is no consensus to date regarding their care, d...

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  • [Radio iodized metaiodobenzylguanidine (MIBG) in the treatment of neuroblastoma: modalities and indications].

    abstract::Neuroblastoma is the most common pediatric extracranial solid cancer. Patients with metastatic disease at initial diagnosis who are greater than 18  months of age and patients with MycN amplified locoregional tumors are treated with intensive multimodal therapy. While this intensive approach has been shown to improve ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

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    authors: Défachelles AS,Cougnenc O,Carpentier P

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  • [Decision making process in oncology: rationale and delineation of a composite index of relative antitumoral efficacy (In-RATE)].

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  • [Measurement of the kinetics of cell proliferation of cancer of the oropharynx in vivo by the incorporation of bromodeoxyuridine and flow cytometry].

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    journal_title:Bulletin du cancer

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    doi:

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  • Biochemical aspects of chemical carcinogenesis.

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    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Gielen JE

    更新日期:1978-01-01 00:00:00

  • Latent infection of mouse cells with human cytomegalovirus.

    abstract::Infection of secondary mouse fibroblast cultures with human cytomegalovirus (HCMV) led to the production of viral antigens in the absence of detectable virus replication. Antigen production was not dependent on viral DNA synthesis since it was not inhibited by cytosine arabinoside. Beginning at 15 days post-infection,...

    journal_title:Bulletin du cancer

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    doi:

    authors: Boldogh I,Gönczöl E,Gärtner L,Vaczi L,Michelson S

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  • [Locoregional recurrence of ORL cancer: the place of surgery].

    abstract::Surgery of locoregional failures is mainly represented by salvage surgery after radiotherapy. Due to progress of radiotherapy, especially modification of fractionation and association with chemotherapy, the problem of salvage surgery is nowadays emphasized. Despite the reduction of postoperative mortality and morbidit...

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  • [Sentinel node biopsy in breast cancer].

    abstract::As compared to conventional axillary dissection, the sentinel node technique is accompanied by reduced morbidity and shorter hospital stay. Based on available data, the use of this technique does not seem to yield higher rates of axillary recurrence. A combination of both radioisotope detection and blue dye increases ...

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    doi:10.1684/bdc.2009.0879

    authors: Hindié E,Groheux D,Espie M,Bourstyn E,Toubert ME,Sarandi F,de Roquancourt A,Giacchetti S,Cuvier C,Cahen-Doidy L,Teyton P,Misset JL,Maylin C,Moretti JL

    更新日期:2009-06-01 00:00:00

  • [Cervical pathology: significance and therapeutic impact of margin status].

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    更新日期:2008-12-01 00:00:00

  • [Opioid switch and change of route of administration in cancer patients treated by morphine].

    abstract::This paper reviewed the 2002 guidelines established by the National Federation of Cancer Centres. A group of experts nominated by the 3 French Societies involved in the treatment of cancer pain (AFSOS, SFAP, SFETD), established new guidelines ratios for morphine switching and/or changing of route of administration, in...

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