[Pharmacologic bases of chemotherapy of brain tumors in children].

Abstract:

:In terms of pharmacology, drug delivery is an important obstacle in the development of brain tumor chemotherapy. The blood-brain barrier limits the drug penetration in normal brain tissue around the tumor and at distant potential metastatic sites. In the tumor, the altered blood-brain barrier, ie blood-tumor barrier, decreases the drug entry in malignant cells. The knowledge of the blood-brain barrier physiology and the definition of the laws that govern the drug delivery to the central nervous system allow the development of new strategies to increase drug delivery to the tumor. In pediatric oncology, the more appropriate methods are the use of anticancer agents that easily cross the blood-brain barrier and the development of high-dose systemic chemotherapy regimens with or without bone marrow rescue.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Vassal G

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

699-713

issue

7

eissn

0007-4551

issn

1769-6917

journal_volume

77

pub_type

杂志文章
  • [The surrogate: Partner in the shared decision-making].

    abstract:UNLABELLED:The legislative process of the surrogate appears to be unclear to health professionals and to patients and next of kin. To better adapt this process to the clinical practice our objective was here to document how the persons designated as surrogate perceived their role and how they described the difficulties...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1016/j.bulcan.2016.03.003

    authors: Sarradon-Eck A,Capodano G,Bureau E,Julian-Reynier C

    更新日期:2016-07-01 00:00:00

  • [Effectiveness of a supportive care form for family physicians].

    abstract::To assess the effectiveness of a standardized form in altering family physicians knowledge regarding supportive care delivered to their patients. We conducted an uncontrolled before and after study involving 42 cancer patients who were provided with supportive care at hospital. During the intervention study period, a ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2011.1452

    authors: Fouquereau J,Laval G,Labarère J

    更新日期:2011-10-01 00:00:00

  • [Allogeneic haematopoietic cell transplantation for diffuse large B cell lymphoma: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

    abstract::Despite great improvements in the outcome of patients with lymphoma, some may still relapse or present with primary refractory disease. In these situations, allogeneic hematopoietic cell transplantation is a potentially curative option, this is true particularly in the case of after autologous stem cell transplantatio...

    journal_title:Bulletin du cancer

    pub_type: 共识发展会议,杂志文章,实务指引,评审

    doi:10.1016/j.bulcan.2017.10.018

    authors: Gauthier J,Chantepie S,Bouabdallah K,Jost E,Nguyen S,Gac AC,Damaj G,Duléry R,Michallet M,Delage J,Lewalle P,Morschhauser F,Salles G,Yakoub-Agha I,Cornillon J

    更新日期:2017-12-01 00:00:00

  • [Particle therapy: carbon ions].

    abstract::Carbon ion therapy is an innovative radiation therapy. It has been first proposed in the forties by Robert Wilson, however the first dedicated centres for human care have been build up only recently in Japan and Germany. The interest of carbon ion is twofold: 1) the very sharp targeting of the tumour with the so calle...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2010.1151

    authors: Pommier P,Hu Y,Baron MH,Chapet O,Balosso J

    更新日期:2010-07-01 00:00:00

  • [Impact of [18F]-FDG-PET on medical decision making in oncology: evaluation by the referring physicians during the opening year].

    abstract::The first study evaluating directly by the referring physician the clinical impact of [18F]-FDG-PET on modification of patient's management was performed only recently in California by means of a questionnaire. We have used the same methodology to evaluate this clinical impact during the opening year of our PET centre...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Talbot JN,Rain JD,Meignan M,Askienazy S,Grall Y,Bok B,Misset JL

    更新日期:2002-03-01 00:00:00

  • [Cancer of the prostate: the markers other than prostatic acid phosphatase].

    abstract::The biological diagnosis of prostatic carcinoma in relation with benign prostatic hypertrophy is essentially realized by the evaluation of plasma PAP or medullar PAP, the increase of which rises to 70% of the cases. This evaluation contains also other biochemical markers such as CK-BB, glucose-6-phosphate dehydrogenas...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Soula G

    更新日期:1985-01-01 00:00:00

  • [Supportive care for survivors].

    abstract::Advances in early detection and treatment have pushed in a few decades the management of cancers from a management model of the end of life to the management of a chronic disease. This evolution has accelerated the development of supportive care in two directions, firstly towards the best possible support to the end o...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2018.04.007

    authors: Ninot G,Debourdeau P,Blanc-Legier F,De Crozals F,De Rauglaudre G,Khouri S,Kirscher S,Mineur L,Piollet I,Sant I,Schillinger P,Serin D

    更新日期:2018-09-01 00:00:00

  • [Asbestos and malignant pleural mesothelioma: molecular, cellular and physiopathological aspects].

    abstract::Asbestos is known as mutagenic and carcinogenic for human and is responsible for many pulmonary diseases including asbestosis, bronchogenic carcinoma and malignant pleural mesothelioma. Occupational exposure to asbestos is involved in 70-80% of all malignant pleural mesothelioma. The later presents a growing challenge...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Mohr S,Keith G,Rihn B

    更新日期:2005-11-01 00:00:00

  • [Rapamycin and CCI-779].

    abstract::Rapamycin (sirolimus) is a macrolide, related to cyclosporine with immunosuppressive properties and antiproliferative activity in various human tumor cells lines and tumor xenograft models. The cytosolic kinase mTOR which controls the initiation of the translation of messenger RNA is the main known target of rapamycin...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Alexandre J,Raymond E,Armand JP

    更新日期:1999-10-01 00:00:00

  • [Percutaneous ablation of metastases: where are we and new techniques].

    abstract::When a metastatic disease is localized and slowly evolving either spontaneously or after a general treatment, a local treatment may be proposed. For about 15 years, image-guided percutaneous ablation has been developed which allows to treat tumors with temperature modifications. These mini-invasive techniques may be r...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2013.1728

    authors: Palussière J,Buy X,Fonck M

    更新日期:2013-04-01 00:00:00

  • [Adjuvant chemotherapy in cancers of the stomach, pancreas and intestine].

    abstract::Adjuvant chemotherapy after apparently complete resection of gastrointestinal cancer may be theoretically justified by the high rate of local and metastatic recurrences. However, the results of controlled trials are generally disappointing, even if some of them have recently suggested some hope, chiefly for adjuvant t...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Martin F

    更新日期:1984-01-01 00:00:00

  • Immunothérapie des glioblastomes.

    abstract:IMMUNOTHERAPY IN GLIOBLASTOMAS:Targeting the immune system as a therapeutic strategy in solid tumors has shown great efficacy in various tumor types. However the role and success of this approach in glioblastomas remain to be determined. Recent studies demonstrated that central nervous system is no longer considered as...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/S0007-4551(18)30391-6

    authors: Baldini C,Romano PM,Varga A,Champiat S,Dumont S,Dhermain F,Louvel G,Marabelle A,Postel-Vinay S,Angevin E,Gazzah A,Ribrag V,Bahleda R,Michot JM,Hollebecque A,Soria JC,Massard C

    更新日期:2018-12-01 00:00:00

  • [Clinical development of anti-angiogenic agents in 2002].

    abstract::In 2002, new developments in anti-angiogenic strategies encompassed two main aspects. Firstly, essential improvements were made in the field of methodology : novel techniques permitted to measure directly on patients the biological effects induced by anti-angiogenic treatments in the course of clinical trials. Secondl...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Bachelot T,Jouanneau E,Blay JY

    更新日期:2003-01-01 00:00:00

  • [Neoadjuvant approach for non-metastatic rectal cancer combining radiotherapy and chemotherapy. Biotargeted drugs].

    abstract::Neoadjuvant chemoradiotherapy is considered at the present time as the standard treatment of most T3-4 rectal cancer. In France a combination of radiotherapy (45 Gy/5 weeks) with concurrent capecitabine (1,600 mg/m2) is the most popular protocol. Randomized trials try to optimize this approach using new cytotoxic drug...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2009.0838

    authors: Gérard JP,Francois E,Deustch E,Rostom Y,Douar N,Benezery K,Milano G

    更新日期:2009-03-01 00:00:00

  • [Chemotherapy combining vindesine, thiotepa and methotrexate in metastatic breast cancer after failure of a combination containing anthracycline. Results of a prospective phase II trial].

    abstract::Twenty-six patients with metastatic breast cancer where treated, after failure of a first line chemotherapy including an anthracycline, with a second line combination of vindesine, methotrexate and thiotepa. Overall tolerance of this treatment was good. There were one complete response and two partial responses. The a...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Comoz M,Chevallier B,Bastit P

    更新日期:1988-01-01 00:00:00

  • Expression of class III beta tubulin in non-small cell lung cancer is correlated with resistance to taxane chemotherapy.

    abstract::This study determined the prevalence and the prognostic value of the expression of microtubule components in tumors of 19 patients with non small cell lung cancer receiving taxane-based regimens. Patient samples were stained with antibodies directed against total beta tubulin, classes I, II and III beta tubulin isotyp...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Dumontet C,Isaac S,Souquet PJ,Bejui-Thivolet F,Pacheco Y,Peloux N,Frankfurter A,Luduena R,Perol M

    更新日期:2005-02-01 00:00:00

  • [Fertility and the progeny of children surviving cancer treatment (author's transl)].

    abstract::Little is known about the late effects of damage to the gonads in children treated for cancer. This investigation requires a prolonged surveillance. Radiotherapy sterilizes the ovaries above a dose of about 500 rads in an adult. Therefore, to protect at least one ovary in partial irradiation of a child's abdomen in ma...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Flamant F,Schweisguth O

    更新日期:1979-01-01 00:00:00

  • [Use of maintenance therapy and complete discontinuation for therapeutic management of non-resectable metastatic colorectal cancer].

    abstract::Management of unresectable metastatic colorectal cancer dramatically changed over the past 20 years. News standards of care combine cytotoxic drugs like fluoropyrimidines, irinotecan and oxaliplatin, with targeted therapies such as anti-EGFR monoclonal antibodies and anti-angiogenic agents. Survival benefit results fr...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2014.1984

    authors: Senellart H,Hiret S,Guerin-Meyer V,Bennouna J

    更新日期:2014-06-01 00:00:00

  • [Renovascular effects of antiangiogenic drugs].

    abstract::During the last decade, inhibitors of the vascular endothelial growth factor (VEGF) were developed for the treatment of cancer. Many anti-VEGF are available but the issue is still the same: to inhibit the effect of the VEGF on their receptors. There are two main classes, depending on the mechanism of action by blockin...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2016.05.005

    authors: Deray G,Janus N,Aloy B,Launay-Vacher V

    更新日期:2016-07-01 00:00:00

  • [Role of psychological factors in cancerogenesis and the development of cancerous disease].

    abstract::Psychoanalysts working in cancerology have to face three main difficulties concerning their methodology: the selection of representative populations, the identification of prospective factors and the choice and definition of the data they need to collect. Four examples are given hereafter: a prospective study on the p...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Raimbault E

    更新日期:1986-01-01 00:00:00

  • [Hospital teaching of oncology].

    abstract::Theoretical teaching of oncology was improved, 15 years ago, by individualizing a special university course during medical studies in France. However medical students need also practical exercising by relation with cancer patients. The main goals may be defined and given to students at the beginning of practical cours...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Hoerni B,Vrousos C

    更新日期:1985-01-01 00:00:00

  • [Announcing cancer diagnosis: which communication difficulties from professional and from patient's side? Which possible improvements?].

    abstract::Announcing a cancer diagnosis, but also a relapse, a progression of the disease, or transition towards palliative care constitute particularly difficult communication issues for the patient as well as for the clinician, during the trajectory of care. The objectives of this article is to present the clinical stakes of ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2010.1197

    authors: Dolbeault S,Brédart A

    更新日期:2010-10-01 00:00:00

  • [Pulmonary malt lymphoma].

    abstract::This review will describe the current knowledge in the pathophysiology, diagnosis, prognosis and treatment of pulmonary MALT (Mucosa Associated Lymphoid Tissue) lymphoma. Pulmonary MALT lymphomas are low-grade B cell lymphoma and are the most frequent lymphomas arising from the lung. Tumour cells arise from mucosa ass...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1684/bdc.2014.1885

    authors: Borie R,Antoine M,Cadranel J,Wislez M

    更新日期:2014-02-01 00:00:00

  • [Frequency of cancer in France: 2004 update].

    abstract::The most recent cancer mortality and morbidity data available for France are presented. In 1999, cancers are the first cause of death among men (87,000 deaths) and the second most common among women (57,000 deaths) after cardiovascular diseases. Lung cancer is the most common cause of cancer death (21,000) in the male...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Hill C,Doyon F

    更新日期:2004-01-01 00:00:00

  • [Following communications made at American Society of Clinical Oncology 2010, what will change our practice? The point of view of the editorial board of Bulletin du Cancer].

    abstract::The congress of Asco made the object of numerous summaries of congress made in the heat of the moment and the Bulletin du Cancer decided to ask to his editorial board, a digested summary, at distance of the congress, to try to sum up the data of the congress which are going to change practice. Of the considerable numb...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:10.1684/bdc.2010.1221

    authors: André T,Wislez M,Goncalves A,de La Motte Rouge T,Blay JY,Massard C,Bay JO,comité de rédaction du Bulletin du Cancer.

    更新日期:2010-12-01 00:00:00

  • [Squamous cell anal carcinoma. What's next ?]

    abstract::Despite its status as a rare disease, the incidence of the squamous cell carcinoma of the anus (SCCA) is surging, especially in its metastatic form. In addition, the prognosis of initially localized diseases has not substantially changed since the 1970s with a recurrence rate of between 25-40 % after the chemoradiothe...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:10.1016/j.bulcan.2020.12.001

    authors: Kim S,Spehner L,Cabel L,Bidard FC,Borg C

    更新日期:2021-01-01 00:00:00

  • [Ataxia telangiectasia: what impact in clinical oncology?].

    abstract::Ataxia telangiectasia (AT) is a hereditary disease transmitted in a recessive mode and characterized by chromosomal instability and radiosensitivity. AT patients have a 100-fold higher risk of cancer than the general population. Although AT is a rare disease of which the frequency has been estimated to be 1/40,000, th...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Stoppa-Lyonnet D,Aurias A

    更新日期:1992-01-01 00:00:00

  • [2 malignant cell lines derived from strain L6 of rat myogenic cells].

    abstract::A nonfusing variant M4 of the L6 line of rat myoblasts was isolated. This subline was tumorigenic when inoculated into suckling rats. Comparative studies of cells growth in vitro, serum requirement, cell adhesiveness and capacity to form colonies in soft agar confirmed that M4 cells had undergone neoplastic transforma...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Hillion J,Leibovitch MP,Leibovitch SA,Harel J

    更新日期:1982-01-01 00:00:00

  • [Clinical activity spectrum of irinotecan].

    abstract::Irinotecan (CPT11), a topoisomerase I inhibitor, is a new cytotoxic agent with a broad spectrum of clinical activity. Two main schedules have been studied and produce similar activity and side-effects: the "european" one--350 mg/m2 every 21 days-, and the "japanese-north american" one where CPT11 is given at a weekly ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Cottu PH,Extra JM,Lerebours F,Espie M,Marty M

    更新日期:1998-12-01 00:00:00

  • [Dynamic characterization of the growth of brain tumors based on image sequences of nuclear magnetic resonance].

    abstract::The evolution of a high grade glioblastoma of a patient undergoing radio-therapy has been analysed by considering a mathematical model which simulates the brain tumour growth within a two-dimensional domain defined by the brain and ventricles geometry. This simulated behaviour was compared with morphological data obta...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Tracqui P,Leitner F,Esteve F

    更新日期:1995-12-01 00:00:00