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Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study.

Abstract：

BACKGROUND:The aim of this study was to prospectively duplicate previous retrospective findings showing that prestorage leukoreduction blunts the detrimental effect of aging on banked packed red blood cells transfused after injury. METHODS:Over 19 months, trauma patients transfused with ≥4 U of packed red blood cells and surviving ≥24 hours were followed. The age of each unit was collected. RESULTS:The cohort consisted of 153 patients. All models showed no association between advancing blood age and the likelihood of developing multiple-organ dysfunction syndrome or infections, regardless of whether the mean age of blood was analyzed as a continuous variable, as a percentage of blood received that was <14 days old, or as a dichotomized value >14 or <14 days old. CONCLUSIONS:This prospective study duplicates previous retrospective findings of an abrogation of the detrimental effects of advancing mean packed red blood cell age on outcomes after trauma by performing prestorage leukoreduction.

journal_name

Am J Surg

journal_title

American journal of surgery

authors

Phelan HA,Eastman AL,Aldy K,Carroll EA,Nakonezny PA,Jan T,Howard JL,Chen Y,Friese RS,Minei JP

doi

10.1016/j.amjsurg.2011.05.012

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

198-204

issue

2

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(11)00441-7

journal_volume

203

pub_type

临床试验,杂志文章

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