Does donor race still make a difference in deceased-donor African-American renal allograft recipients?

Abstract:

BACKGROUND:Prior studies have demonstrated that African-American (AA) donor kidneys are independently associated with an increased risk for graft loss. METHODS:We examined outcomes in comparable groups of AA deceased-donor (DD) kidney transplant patients receiving an AA donor (n=35) versus a Caucasian donor (C group; n=150) organ. RESULTS:There were no differences between AA and C groups in patient survival, new-onset diabetes, or BK nephropathy. The AA group demonstrated a significantly higher 6-month and overall incidence of acute rejection (AR), increased cytomegalovirus (CMV) infection, and decreased graft survival. Recurrent or de novo focal segmental glomerulosclerosis (FSGS) accounted for a significantly higher fraction of graft losses in the AA versus C group. CONCLUSIONS:AA DD renal allograft recipients have equivalent patient but decreased graft survival when transplanted with an AA versus C kidney using current immunosuppression. This may be the result of increased AR, CMV infection, and recurrence/development of FSGS.

journal_name

Am J Surg

authors

Brown KL,Doshi MD,Singh A,Mehta K,Morawski K,Cincotta E,West MS,Gruber SA

doi

10.1016/j.amjsurg.2009.08.025

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

305-9; discussion 309

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(09)00684-9

journal_volume

199

pub_type

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