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Combined modality therapy utilizing a cisplatin combination for effective chemotherapy in patients with previously untreated head and neck cancer.

Abstract：

:In patients with locally advanced head and neck cancer, the results of standard definitive treatments of surgery, radiotherapy, or both were disappointing. The local and regional recurrence rates were high, despite adequate surgical resection with negative margins and postoperative radiotherapy to all known or possible disease areas. Combination cisplatin chemotherapy given initially before definitive treatments produced a high overall antitumor response and up to 50 percent clinical complete response. Before answering the question of value of chemotherapy as part of the multimodality treatment, it is important to identify the safest and most form of chemotherapy. The degre of chemotherapy effectiveness is defined by the incidence of clinical and, most important, histologic complete response. To assess this effectiveness, chemotherapy was given before definitive treatments to patients with measurable disease. From our 10 year experience we have concluded that continuing the development of induction chemotherapy, including investigating the timing of such effective treatment and assessing the value of such therapy, is of the utmost importance.

journal_name

Am J Surg

journal_title

American journal of surgery

authors

Jacobs JR,Kish J,Ensley JF,Ahmad K,Weaver A,Crissman J,Al-Sarraf M

doi

10.1016/0002-9610(86)90323-5

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

451-5

issue

4

eissn

0002-9610

issn

1879-1883

pii

0002-9610(86)90323-5

journal_volume

152

pub_type

杂志文章

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