Advanced squamous cell carcinoma of the maxillary sinus. Results of combined regional infusion chemotherapy, radiation therapy and surgery.

Abstract:

:Sequential intraarterial chemotherapy using bleomycin and methotrexate followed by high dose radiation and surgery was evaluated in 10 patients with stage III and IV squamous carcinomas of the maxillary sinus. Seven of 10 patients had extensive tumor necrosis in the surgical specimen, and no evidence of residual tumor was found in 4 of these patients. After a median follow up period of 24 months, there has been only one local recurrence in resected patients. Three patients died from pulmonary metastases. Although many unanswered questions remain regarding the efficacy of triple therapy for maxillary sinus malignancy, these results are encouraging and establish that surgical resection and healing are not compromised by preoperative chemotherapy and radiation.

journal_name

Am J Surg

authors

Moseley HS,Thomas LR,Everts EC,Stevens KR,Ireland KM

doi

10.1016/0002-9610(81)90037-4

subject

Has Abstract

pub_date

1981-05-01 00:00:00

pages

522-5

issue

5

eissn

0002-9610

issn

1879-1883

pii

0002-9610(81)90037-4

journal_volume

141

pub_type

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