Role of cortisol in the restitution of blood volume after hemorrhage.

Abstract:

:The restitution of blood volume and plasma protein after 10 per cent hemorrhage was studied in intact dogs and in dogs subjected to adrenalectomy and infused with cortisol at basal or physiologically increased rates. The results suggest that increased extracellular osmolality, mediated by an increased secretion of cortisol, mediates, in turn, the restitution of protein and plasma volume. The results are best explained by the hypothesis that after hemorrhage, as a direct result of an increased secretion of cortisol, extracellular osmolality increases. A shift of fluid from cells to interstitium follows, increasing the interstitial pressure. This latter increase leads to an increased return of protein through the lymphatics and to an increased return of fluid through both lymphatics and capillaries.

journal_name

Am J Surg

authors

Gann DS,Pirkle JC Jr

doi

10.1016/0002-9610(75)90513-9

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

565-9

issue

5

eissn

0002-9610

issn

1879-1883

pii

0002-9610(75)90513-9

journal_volume

130

pub_type

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