Oral choline supplementation in children with intestinal failure.

Abstract:

:Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.

authors

Guerrerio AL,Mattis L,Conner KG,Hampsey J,Stasinopoulos DM,DeJong R,Boctor EM,Sheth S,Hamper UM,Scheimann AO

doi

10.1097/MPG.0b013e31821404d4

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

115-9

issue

1

eissn

0277-2116

issn

1536-4801

pii

00005176-201107000-00023

journal_volume

53

pub_type

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