Zinc therapy for diarrhoea improves growth among Bangladeshi infants 6 to 11 months of age.

Abstract:

OBJECTIVES:We assessed the effect of zinc for the treatment of diarrhoea implemented at the community level on physical growth among children 6 to 35 months of age. METHODS:The service areas of 30 community health workers in the Matlab field site of International Centre for Diarrhoeal Disease Research, Bangladesh, were randomly allocated to the intervention or comparison study arm. Between November 1998 and October 2000, caretakers of 3- to 59-month-old children with diarrhoea in both intervention and comparison areas were offered oral rehydration solution and feeding advice, and severe episodes were referred for facility-based care. The caretakers of the children in the intervention area were additionally offered 20 mg/day elemental zinc for 14 days as adjunct treatment for each diarrhoea episode. Weight and length of children who were 6 to 11 months of age at the beginning of the study were measured every 2 months for 2 years. Rates of length and weight gains were compared between children living in intervention and control arms using a latent growth model. RESULTS:Characteristics of children living in control and intervention areas were similar, except that more children living in intervention areas were underweight at baseline (44 vs 35%; P = 0.02). Children living in intervention clusters gained slightly more weight and length than children in the control clusters (86.4 g/year and 2.8 mm/year, respectively). CONCLUSIONS:The therapeutic use of zinc along with oral rehydration solution for community-based diarrhoea management may have a small positive benefit on the rates of growth among children younger than 3 years of age.

authors

Naheed A,Walker Fischer CL,Mondal D,Ahmed S,Arifeen SE,Yunus M,Black RE,Baqui AH

doi

10.1097/MPG.0b013e31817f0182

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

89-93

issue

1

eissn

0277-2116

issn

1536-4801

pii

00005176-200901000-00015

journal_volume

48

pub_type

杂志文章,随机对照试验
  • Progressive familial intrahepatic cholestasis among the Arab population in Israel.

    abstract:BACKGROUND:Progressive familial intrahepatic cholestasis, which constitutes a heterogeneous group of imperfectly delineated syndromes and appears to be inherited as an autosomal recessive condition, has not been hitherto reported from the Middle East, in spite of the high rate of consanguineous marriage in this region....

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199705000-00011

    authors: Naveh Y,Bassan L,Rosenthal E,Berkowitz D,Jaffe M,Mandel H,Berant M

    更新日期:1997-05-01 00:00:00

  • Quantitative Analysis of Apparent Diffusion Coefficient for Disease Assessment in Paediatric Inflammatory Bowel Disease.

    abstract:OBJECTIVE:The aim of the study was to establish an apparent diffusion coefficient (ADC) cut-off value to classify active and non-active lesions in inflammatory bowel disease. METHODS:We reviewed 167 paediatric magnetic resonance enterographies executed for suspected inflammatory bowel disease by using a 1.5- and 3-T s...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002178

    authors: Scionti A,Di Maurizio M,Basile M,Bernardini A,Miccoli M,Lionetti P,Defilippi C,Caramella D

    更新日期:2019-03-01 00:00:00

  • In vitro effects of sera from children with acute liver failure on metabolic and synthetic activity of cryopreserved human hepatocytes.

    abstract:OBJECTIVE:The aim of the study was to investigate the in vitro effects of sera from children with acute liver failure (ALF) who had received N-acetylcysteine (NAC) on the metabolic and synthetic activity of cryopreserved human hepatocytes. MATERIALS AND METHODS:Cryopreserved human hepatocytes were plated on collagen-c...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31819114da

    authors: Mitry RR,Bansal S,Hughes RD,Mieli-Vergani G,Dhawan A

    更新日期:2009-05-01 00:00:00

  • Ascites complicating ventriculoperitoneal shunts.

    abstract::Ventriculoperitoneal shunts are currently a standard therapy for obstructive hydrocephalus. These shunts are associated with a variety of abdominal complications, one of which is the development of ascites. We report an 11-year-old girl with a ventriculoperitoneal shunt in whom a low-grade peritoneal infection present...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198809000-00028

    authors: Goodman GM,Gourley GR

    更新日期:1988-09-01 00:00:00

  • Carcinoid tumor of the appendix in childhood: the experience of two Italian institutions.

    abstract:OBJECTIVES:Although rare, carcinoid tumor of the appendix is the most common neoplasm of the gastrointestinal tract in children and adolescents. It is usually an incidental finding after a laparotomy for appendectomy, with a frequency of 2 to 5 cases per 1000 appendectomies. The experience with 14 cases of carcinoid re...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200502000-00025

    authors: Dall'Igna P,Ferrari A,Luzzatto C,Bisogno G,Casanova M,Alaggio R,Terenziani M,Cecchetto G

    更新日期:2005-02-01 00:00:00

  • Alanine-based oral rehydration solution: assessment of efficacy in acute noncholera diarrhea among children.

    abstract::This randomized, double-blind trial determined whether adding 90 mmol/L of alanine with a reduction in glucose to 90 mmol/L (alanine ORS) improves the efficacy of the standard oral rehydration solution (WHO-ORS). One hundred twenty-nine males aged 3-48 months with weight for length greater than or equal to 70% of NCHS...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sazawal S,Bhatnagar S,Bhan MK,Saxena SK,Arora NK,Aggarwal SK,Kashyap DK

    更新日期:1991-05-01 00:00:00

  • Doxycycline-induced hemorrhagic esophagitis: a pediatric case.

    abstract::Esophagitis induced by medications has been recognized in adults but rarely in children. A child with hemorrhagic esophagitis resulting from taking doxycycline tablets for treatment is described and the pathophysiology of this condition is discussed. In pediatric cases treated by tablets or capsules, the possibility o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198809000-00023

    authors: Kato S,Kobayashi M,Sato H,Saito Y,Komatsu K,Harada Y

    更新日期:1988-09-01 00:00:00

  • Development and testing of a CD-ROM program for improving adolescent knowledge of inflammatory bowel disease.

    abstract:OBJECTIVE:The aim of this study was to design a theory-based educational program for adolescents with inflammatory bowel disease (IBD) using an interactive multimedia CD-ROM and to test its effectiveness in improving knowledge in IBD. MATERIALS AND METHODS:Curriculum-based instruction using educational theory and prin...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181b1356a

    authors: Boamah LM,Bohren JR,Pentiuk S,Baker R,Yi M,Moyer MS

    更新日期:2010-05-01 00:00:00

  • A New Domain Structure for the IMPACT-III Health-related Quality of life Tool for Pediatric Inflammatory Bowel Disease.

    abstract:BACKGROUND:The IMPACT-III measures health-related quality of life (HRQOL) in pediatric patients with Inflammatory Bowel Disease (IBD). The original IMPACT domain structure was developed based on expert opinion and was not psychometrically validated. This study developed a new domain structure based on the current IMPAC...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002824

    authors: Grant A,MacIntyre B,Kappelman MD,Otley AR

    更新日期:2020-10-01 00:00:00

  • Portal hypertension secondary to congenital arterioportal fistula.

    abstract::An infant boy with severe portal hypertension developed failure to thrive and malabsorption. Clinical findings and ultrasonography suggested the presence of an arteriovenous shunt, and hepatic angiography confirmed the diagnosis and outlined the anatomy of the vascular malformation, which was an intrahepatic arteriopo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198705000-00027

    authors: Iñon AE,D'Agostino D

    更新日期:1987-05-01 00:00:00

  • Chronic gastroenteritis in a patient with histiocytosis-X.

    abstract::We describe a 5-year-old white girl who presented at 18 months of age with an ileal perforation and radiographic evidence of segmental intestinal narrowing. Her initial diagnosis was Crohn's disease; however, on subsequent microscopic review, her lesion consisted of mixed histiocytic and eosinophilic infiltration char...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Sutphen JL,Fechner RE

    更新日期:1986-03-01 00:00:00

  • Management of cyclic vomiting syndrome.

    abstract::The general goals of treatment of cyclic vomiting syndrome (CVS) are: interruption of established episodes, amelioration of symptoms in patients whose episodes cannot be interrupted, aborting episodes during prodromal symptoms, prophylaxis to abolish or lessen the frequency of episodes, and recovery. Complications of ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-199501001-00015

    authors: Fleisher DR

    更新日期:1995-01-01 00:00:00

  • Efficacy and Safety of Sodium Benzoate in The Management of Hyperammonemia in Decompensated Chronic Liver Disease of the Childhood-A Double-blind Randomized Controlled Trial.

    abstract:OBJECTIVE:The objective was to evaluate the efficacy and safety of sodium benzoate in the management of hyperammonemia and hepatic encephalopathy (HE) in decompensated chronic liver disease. METHODS:It was a prospective, interventional, double-blinded randomized controlled trial conducted from August 2017 to December ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002521

    authors: Snehavardhan P,Lal BB,Sood V,Khanna R,Alam S

    更新日期:2020-02-01 00:00:00

  • Presymptomatic Diagnosis of Celiac Disease in Predisposed Children: The Role of Gene Expression Profile.

    abstract:OBJECTIVE:The prevalence of celiac disease (CD) has increased significantly in recent years, and risk prediction and early diagnosis have become imperative especially in at-risk families. In a previous study, we identified individuals with CD based on the expression profile of a set of candidate genes in peripheral blo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001519

    authors: Galatola M,Cielo D,Panico C,Stellato P,Malamisura B,Carbone L,Gianfrani C,Troncone R,Greco L,Auricchio R

    更新日期:2017-09-01 00:00:00

  • Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era.

    abstract::Thiopurines are used as a maintenance therapy in patients with ulcerative colitis (UC). For some patients the metabolism of thiopurines is unfavorable, leading to increased adverse effects, including hepatotoxicity. There are many reports in the adult literature concerning the manipulation of thiopurine metabolism wit...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000344

    authors: Ihekweazu FD,Kellermayer R

    更新日期:2014-07-01 00:00:00

  • First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radioimmunoassay in 5000 Italian primary schoolchildren.

    abstract:OBJECTIVE:The high prevalence of celiac disease (CD) prompted us to evaluate a new, noninvasive disease screening strategy. The aim was to identify CD in 6- to 8-year-old children for a timely diagnosis, start gluten-free diet (GFD) in compliant subjects, achieve the growth target, and prevent CD complications. METHOD...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181e6f2d0

    authors: Bonamico M,Nenna R,Montuori M,Luparia RP,Turchetti A,Mennini M,Lucantoni F,Masotti D,Magliocca FM,Culasso F,Tiberti C

    更新日期:2011-01-01 00:00:00

  • Ultrasonographic diagnosis of midgut volvulus with malrotation in children.

    abstract:OBJECTIVES:Midgut volvulus with malrotation is typical in newborns. We present our experience to emphasize the importance of suspecting midgut volvulus as a cause of abdominal pain also beyond infancy, particularly in relation to malrotation, and the relevance of ultrasonographic (US) signs in its diagnosis. METHODS:A...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000505

    authors: Esposito F,Vitale V,Noviello D,Di Serafino M,Vallone G,Salvatore M,Oresta P

    更新日期:2014-12-01 00:00:00

  • Gastric acid hypersecretion in short bowel syndrome in infants: association with extent of resection and enteral feeding.

    abstract::To determine the frequency of gastric acid hypersecretion in infants with chronic malabsorption due to short bowel syndrome, acid secretory function was determined in 23 infants with malabsorption 2-22 months following small bowel resection and in a control group of 14 chronically ill, age- and weight-matched infants ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Hyman PE,Everett SL,Harada T

    更新日期:1986-03-01 00:00:00

  • The management of enzymatic therapy in cystic fibrosis patients by an individualized approach.

    abstract::We evaluated nutritional status, pulmonary impairment, nutritional intake, and fat absorption in 73 cystic fibrosis (CF) patients to identify the primary factor(s) influencing growth. In general, the growth pattern in our patients was satisfactory since 60/73 were not underweight. When caloric intake is greater than o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198811001-00008

    authors: Costantini D,Padoan R,Curcio L,Giunta A

    更新日期:1988-01-01 00:00:00

  • Oral microbial profile discriminates breast-fed from formula-fed infants.

    abstract:OBJECTIVES:Little is known about the effect of diet on the oral microbiota of infants, although diet is known to affect the gut microbiota. The aims of the present study were to compare the oral microbiota in breast-fed and formula-fed infants, and investigate growth inhibition of streptococci by infant-isolated lactob...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31826f2bc6

    authors: Holgerson PL,Vestman NR,Claesson R,Ohman C,Domellöf M,Tanner AC,Hernell O,Johansson I

    更新日期:2013-02-01 00:00:00

  • Polyethylene glycol: a game-changer laxative for children.

    abstract::Constipation is a common problem in children worldwide. It can also be a chronic problem persisting for many months to years. Successful treatment of constipation requires long-term use of laxatives. Commonly used laxatives in children include milk of magnesia, lactulose, mineral oil, and polyethylene glycol. Compared...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e318296404a

    authors: Alper A,Pashankar DS

    更新日期:2013-08-01 00:00:00

  • Sub-10-minute High-quality Diagnostic Colonoscopy With Terminal Ileum Intubation in Children Is Feasible and Safe.

    abstract:OBJECTIVES:To critically appraise ileocolonoscopy (IC) practice in a large tertiary center, where IC is exclusively performed by experienced pediatric colonoscopists, particularly focusing on indications for the procedure; bowel preparation efficacy; IC completion rates and timings; diagnostic yield; and complications....

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002326

    authors: Thomson M,Eltumi M,Singh C,Eyles M,Shah N,Vadamalayan B,Chong S,Thapar N,D'Ambrosio A,Isoldi S

    更新日期:2019-07-01 00:00:00

  • Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in cambodian infants.

    abstract:OBJECTIVES:To assess and compare efficacy of two micronutrient sprinkle supplementation on growth, anemia, and iron deficiency in Cambodian infants. METHODS:A total of 204 infants aged 6 months and living in Kompong Chhnang Province, Cambodia were randomly assigned to receive daily supplements of either iron (12.5 mg)...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.mpg.0000189363.07040.4b

    authors: Giovannini M,Sala D,Usuelli M,Livio L,Francescato G,Braga M,Radaelli G,Riva E

    更新日期:2006-03-01 00:00:00

  • Supplementation of milk with iron bound to lactoferrin using weanling mice: L. Effects on hematology and tissue iron.

    abstract::Lactoferrin is an iron-binding protein present in high concentrations in human milk. The efficacy of supplementing iron bound to lactoferrin to iron-deficient and iron-sufficient young mice was evaluated in comparison with supplementation of iron as iron chloride. Mice fed a nonsupplemented milk diet (approximately 1 ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198311000-00021

    authors: Fransson GB,Keen CL,Lönnerdal B

    更新日期:1983-11-01 00:00:00

  • Celiac Disease and Wheat Intolerance Syndrome: A Critical Update and Reappraisal.

    abstract::Since the first description of celiac disease (CeD) by Samuel Gee in 1888 and the later "miraculous discovery" that bread was responsible for this condition following World War II in Europe, there has been an exponential growth of knowledge regarding CeD. Just when we thought that we knew everything there was to know ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001312

    authors: Jericho H,Assiri A,Guandalini S

    更新日期:2017-01-01 00:00:00

  • 14 years of eosinophilic esophagitis: clinical features and prognosis.

    abstract:OBJECTIVE:To determine the natural history of treated and untreated eosinophilic esophagitis (EE) and examine the presenting symptoms of EE. PATIENTS AND METHODS:Retrospective and prospective chart review of all patients diagnosed with EE at The Children's Hospital of Philadelphia. EE was defined as greater than 20 eo...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181788282

    authors: Spergel JM,Brown-Whitehorn TF,Beausoleil JL,Franciosi J,Shuker M,Verma R,Liacouras CA

    更新日期:2009-01-01 00:00:00

  • Ketamine sedation for pediatric gastroenterology procedures.

    abstract:BACKGROUND:Although the dissociative sedative ketamine is used commonly for pediatric procedural sedation in other settings, the safety of this agent in pediatric gastroenterology is not well-studied. A 5-year experience with ketamine sedation for pediatric gastroenterology procedures was reviewed to document the safet...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-200101000-00010

    authors: Green SM,Klooster M,Harris T,Lynch EL,Rothrock SG

    更新日期:2001-01-01 00:00:00

  • Effect of protein source and iron content of infant formula on stool characteristics.

    abstract::Formula-fed, term infants were evaluated in two studies that assessed the influence on stool characteristics of protein source and iron content of the formula. Parental observations of infants' stool characteristics were recorded on standard forms. Green was the primary stool color for infants receiving whey-predomina...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00015

    authors: Malacaman EE,Abbousy FK,Crooke D,Nauyok G Jr

    更新日期:1985-10-01 00:00:00

  • Prevention of rotavirus-induced diarrhea by preferential secretion of IgA in breast milk via maternal administration of Lactobacillus gasseri SBT2055.

    abstract:OBJECTIVES:Rotavirus (RV)-induced diarrhea poses a major health problem, particularly to infants. An effective measure to prevent RV infection is to consume breast milk with higher levels of protective IgA. We therefore examined whether Lactobacillus gasseri SBT2055 (LG2055) could augment immunoglobulin (Ig) A levels a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3182533a2b

    authors: Kadooka Y,Tominari K,Sakai F,Yasui H

    更新日期:2012-07-01 00:00:00

  • Exchangeable Zinc Pool Size at Birth in Pakistani Small for Gestational Age and Appropriate for Gestational Age Infants Do Not Differ But Are Lower Than in US Infants.

    abstract:OBJECTIVES:Small for gestational age (SGA) infants are more susceptible to infectious morbidity and growth faltering compared to their appropriate for gestational age (AGA) counterparts. Zinc supplementation of SGA infants may be beneficial but the underlying susceptibility to zinc deficiency of SGA infants has not bee...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001778

    authors: Ariff S,Krebs NF,Westcott JE,Hambidge M,Miller LV,Rizvi A,Soofi SB,Bhutta ZA

    更新日期:2018-03-01 00:00:00