Microbial DNA topoisomerases and their inhibition by antibiotics.

Abstract:

:Supercoiling of bacterial DNA is regulated by topoisomerases and influences most of the metabolic processes involving DNA. The present review is devoted to a brief outline of the supercoiled state of DNA in bacteria and to all microbial topoisomerases hitherto described. Recent studies on topoisomerases of archaebacteria led to the discovery of a so-called reverse gyrase, the properties of which are also discussed. Special emphasis is given to a selective treatment of the effects of those antibiotics which act as gyrase inhibitors.

journal_name

J Basic Microbiol

authors

Zimmer C,Störl K,Störl J

doi

10.1002/jobm.3620300312

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

209-24

issue

3

eissn

0233-111X

issn

1521-4028

journal_volume

30

pub_type

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