Abstract:
:Candida albicans supernatants contain a mixture of autoregulatory alcohols. In vitro, when added individually or in combination, these alcohols inhibit the yeast to filamentous form conversion. Here we evaluate the in vivo effect of the exogenous administration of a Cocktail solution simulating the composition of alcohols present in a C. albicans culture supernatant (1 ml; 94 μmol l(-1) isoamyl alcohol, 70 μmol l(-1) 2-phenylethanol, 3.2 n mol l(-1) E -nerolidol, and 18 n mol l(-1) E,E -farnesol) using the well established murine model of hematogenously disseminated candidiasis. Mice injected intraperitoneally with the Cocktail solution demonstrated increased survival and decreased organ fungal burden compared to control mice. Histological observations suggest that the Cocktail, to some extent, has an inhibitory effect on cell filamentation within the kidney. These findings suggest that the exogenous administration of C. albicans autoregulatory alcohols displays a protective effect during disseminated candidiasis.
journal_name
J Basic Microbioljournal_title
Journal of basic microbiologyauthors
Martins M,Lazzell AL,Lopez-Ribot JL,Henriques M,Oliveira Rdoi
10.1002/jobm.201100158subject
Has Abstractpub_date
2012-08-01 00:00:00pages
487-91issue
4eissn
0233-111Xissn
1521-4028journal_volume
52pub_type
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