Abstract:
:P16(INK4A) (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic inactivation of the p16(INK4A) (or CDKN2A) gene in virtually all types of human cancers. However, it has also been shown that an elevated level of expression (upregulation) of P16 is involved in cellular senescence, aging, and cancer progression, indicating that the regulation of P16 is critical for its function. Here, we discuss the regulatory mechanisms of P16 function at the DNA level, the transcription level, and the posttranscriptional level, as well as their implications for the structure-function relationship of P16 and for human cancers.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Li J,Poi MJ,Tsai MDdoi
10.1021/bi200642esubject
Has Abstractpub_date
2011-06-28 00:00:00pages
5566-82issue
25eissn
0006-2960issn
1520-4995journal_volume
50pub_type
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