Abstract:
:HcbA1 is a unique flavoenzyme that catalyzes the first step in the bacterial hexachlorobenzene catabolic pathway. Here we report in vitro reconstitution of the HcbA1-catalyzed reaction. Detailed mechanistic studies provide evidence for nucleophilic aromatic substitution and flavin-N5-oxide formation.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Adak S,Begley TPdoi
10.1021/acs.biochem.9b00012subject
Has Abstractpub_date
2019-03-05 00:00:00pages
1181-1183issue
9eissn
0006-2960issn
1520-4995journal_volume
58pub_type
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