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Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts.

Abstract：

:The activity of neutral sphingomyelinase (EC 3.1.4.12) in a plasma membrane enriched fraction was found to be increased in dexamethasone treated cells. The elevation of sphingomyelinase activity was blocked by cycloheximide indicating that protein synthesis was required for the steroid action. Ceramidase (EC3.5.1.23) activity was unaffected by the dexamethasone treatment. Levels of sphingosine in 3T3-L1 Cells were also increased after treatment with 10(-7) M dexamethasone for 2 and 4 hours.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ramachandran CK,Murray DK,Nelson DH

doi

10.1016/0006-291x(90)92068-b

subject

Has Abstract

pub_date

1990-03-16 00:00:00

pages

607-13

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92068-B

journal_volume

167

pub_type

杂志文章

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