Abstract：
:In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics at the University of California, San Francisco and UC Los Angeles completed the PQ-B and the Structured Interview for Prodromal Syndromes (SIPS) at intake. Endorsement of three or more positive symptoms on the PQ-B differentiated between those with prodromal syndrome and psychotic syndrome diagnoses on the SIPS versus those with no SIPS diagnoses with 89% sensitivity, 58% specificity, and a positive Likelihood Ratio of 2.12. A Distress Score measuring the distress or impairment associated with endorsed positive symptoms increased the specificity to 68%, while retaining similar sensitivity of 88%. Agreement was very similar when participants with psychotic syndromes were excluded from the analyses. These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Loewy RL,Pearson R,Vinogradov S,Bearden CE,Cannon TDdoi
10.1016/j.schres.2011.03.029subject
Has Abstractpub_date
2011-06-01 00:00:00pages
42-6issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(11)00177-0journal_volume
129pub_type
杂志文章,多中心研究abstract：:Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks h...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.007
更新日期：2018-10-01 00:00:00
abstract：:Although factor scores are commonly used to interpret the Weschsler Adult Intelligence Scale--Revised (WAIS-R), the WAIS-R factor structure has not been investigated in patients with schizophrenia. We used confirmatory factor analysis (CFA) to examine five latent construct models in 169 males with schizophrenia. The W...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00090-5
更新日期：1998-11-09 00:00:00
abstract：BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibili...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00534-0
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:A definition of clinical remission in schizophrenia has recently been proposed. However, it is also known that neuropsychological (NP) impairments may be better predictors of functional outcomes than clinical symptoms. Understanding the relationship between clinical remission and cognitive improvement may be...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.12.032
更新日期：2007-08-01 00:00:00
abstract：:Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. Recent findings of an incre...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.05.007
更新日期：2005-01-01 00:00:00
abstract：:Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.061
更新日期：2019-12-01 00:00:00
abstract：:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.03.017
更新日期：2009-06-01 00:00:00
abstract：:High exposure to green space and natural environments has previously been associated with lower schizophrenia rates possibly through low air pollution and improved psychological restoration. Exposure to natural environments could explain the negative urban-rural gradient of schizophrenia, but it is unclear if all natu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.10.012
更新日期：2020-02-01 00:00:00
abstract：:Previous transcriptome analyses of brain samples provided several insights into the pathophysiology of schizophrenia. In this study, we aimed to re-investigate gene expression datasets from seven brain regions of patients with schizophrenia and healthy controls by adopting a unified approach. After adjustment for conf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.06.032
更新日期：2020-09-01 00:00:00
abstract：:Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 pat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.032
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：:The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, ...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.10.029
更新日期：2015-04-01 00:00:00
abstract：:The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients. Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in schizophrenia brain tissue samples from the Stanley Array Correc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.06.011
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2008.10.023
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:D-serine is an allosteric modulator of the brain N-methyl-d-aspartate (NMDA) receptor and a potential novel treatment of schizophrenia. Double-blind studies have been performed at 30 mg/kg/day (approximately 2 g/day) with encouraging results, but no formal dose escalation studies have been performed. We desc...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2010.05.012
更新日期：2010-08-01 00:00:00
abstract：:Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of mitochondria in SZ might be confounded by the effects of pharmacological treatment with antipsychotic drugs (APDs) and other common medications. This review summarizes findings on relevant mitochondria mechanisms underlying SZ, an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.09.007
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.03.020
更新日期：2012-06-01 00:00:00
abstract：:Stigma can be a major stressor for individuals with schizophrenia and other mental illnesses. It is unclear, however, why some stigmatized individuals appraise stigma as more stressful, while others feel they can cope with the potential harm posed by public prejudice. We tested the hypothesis that the level of perceiv...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.01.006
更新日期：2009-05-01 00:00:00
abstract：:Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00378-4
更新日期：2002-11-01 00:00:00
abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
更新日期：2016-11-01 00:00:00
abstract：:The content of delusions were studied in a group of schizophrenics and affective disorder patients who had an episodic course to ascertain if the content of delusions remained similar or became dissimilar during different episodes. There were 18 schizophrenics and 30 affective disorder cases in this study. Consistency...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(90)90020-8
更新日期：1990-10-01 00:00:00
abstract：:Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.05.011
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and healthy comparison subjects (HCS). The Consortium on the Genetics of Schizophrenia (COGS) identified associations between PPI and single nucleotide polymorphisms in schizoph...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2013.12.004
更新日期：2014-02-01 00:00:00
abstract：:Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2018.07.019
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.015
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:Recent reports of antibodies to heat shock proteins 60kDa (HSP60) and HSP70 suggested that antibodies to the heat shock protein that plays a protective role against environmental stresses in a cell might be related to the pathogenesis of schizophrenia, although the antibody to HSP90 had not yet been identifi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00091-8
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.002
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:This is a comprehensive study designed to examine the association between specific clusters of neurological abnormalities and several clinically relevant aspects of schizophrenia such as positive and negative symptoms, neurocognitive deficits and psychosocial performance. METHODS:Thirty-seven clinically stab...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(96)00095-3
更新日期：1997-02-07 00:00:00
abstract：:Recent meta-analytic evidence suggests that clinical neuropsychological methods are not likely to uncover circumscribed cognitive impairments in the deficit syndrome of schizophrenia. To overcome this issue, we adapted a cognitive neuroscience perspective and used a new "chaining" habit learning task. Participants wer...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.06.027
更新日期：2008-02-01 00:00:00
abstract：:Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00181-9
更新日期：1999-07-27 00:00:00
