Abstract:
:The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pathway.
journal_name
Mol Celljournal_title
Molecular cellauthors
Brodsky JLdoi
10.1016/j.molcel.2010.09.016subject
Has Abstractpub_date
2010-10-08 00:00:00pages
5-7issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(10)00744-6journal_volume
40pub_type
杂志文章相关文献
MOLECULAR CELL文献大全abstract::Downstream core promoter elements are an expanding class of regulatory sequences that add considerable diversity to the promoter architecture of RNA polymerase II-transcribed genes. We set out to determine the factors necessary for downstream promoter element (DPE)-dependent transcription and find that, against expect...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2005.04.005
更新日期:2005-05-13 00:00:00
abstract::The Fanconi anemia (FA) pathway is implicated in DNA repair and cancer predisposition. Central to this pathway is the FA core complex, which is targeted to chromatin by FANCM and FAAP24 following replication stress. Here we show that FANCM and FAAP24 interact with the checkpoint protein HCLK2 independently of the FA c...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.10.014
更新日期:2008-11-07 00:00:00
abstract::Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is recruited to centromeres through a direct interaction between the HJU...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.014
更新日期:2016-03-03 00:00:00
abstract::Metazoan histone mRNAs are unique: their pre-mRNAs contain no introns, and the mRNAs are not polyadenylated, ending instead in a conserved stem-loop structure. In Drosophila, canonical poly(A) signals are located downstream of the normal cleavage site of each histone gene and are utilized when histone 3' end formation...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.04.024
更新日期:2009-05-15 00:00:00
abstract::Xenopus oocytes can epigenetically reprogram mouse somatic cells toward totipotency. In this issue, Jullien et al. (2014) now describe rapid, interdependent molecular events that facilitate this reprogramming. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2014.08.008
更新日期:2014-08-21 00:00:00
abstract::We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new componen...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)00059-9
更新日期:2000-09-01 00:00:00
abstract::Yeast histone H2A is phosphorylated on Ser129 upon DNA damage, an event required for efficient repair. We show that phosphorylation occurs rapidly over a large region around DNA double-strand breaks (DSBs). Histone H4 acetylation is also important for DSB repair, and we found that the NuA4 HAT complex associates speci...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.12.003
更新日期:2004-12-22 00:00:00
abstract::Copy-number changes generate phenotypic variability in health and disease. Whether organisms protect against copy-number changes is largely unknown. Here, we show that Saccharomyces cerevisiae monitors the copy number of its ribosomal DNA (rDNA) and rapidly responds to copy-number loss with the clonal amplification of...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.08.036
更新日期:2018-11-01 00:00:00
abstract::Mitochondrial crista structure partitions vital cellular reactions and is precisely regulated by diverse cellular signals. Here, we show that, in Drosophila, mitochondrial cristae undergo dynamic remodeling among distinct subcellular regions and the Parkinson's disease (PD)-linked Ser/Thr kinase PINK1 participates in ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.01.026
更新日期:2018-03-01 00:00:00
abstract::Mitochondrial diseases and aging are associated with defects in the oxidative phosphorylation machinery (OXPHOS), which are the only complexes composed of proteins encoded by separate genomes. To better understand genome coordination and OXPHOS recovery during mitochondrial dysfunction, we examined ATFS-1, a transcrip...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.02.008
更新日期:2015-04-02 00:00:00
abstract::The majority of the human genome is transcribed into non-coding (nc)RNAs that lack known biological functions or else are only partially characterized. Numerous characterized ncRNAs function via base pairing with target RNA sequences to direct their biological activities, which include critical roles in RNA processing...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.04.030
更新日期:2016-05-19 00:00:00
abstract::BRAF is an oncogenic protein kinase that drives cell growth and proliferation through the MEK-ERK signaling pathway. BRAF inhibitors have demonstrated antitumor efficacy in melanoma therapy but have also been found to be associated with the development of cutaneous squamous cell carcinomas (cSCCs) in certain patients....
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.08.044
更新日期:2013-10-24 00:00:00
abstract::BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently it recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1-deficient cells by increasing resecti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.12.010
更新日期:2019-03-21 00:00:00
abstract::The Polycomb repressive system is an essential chromatin-based regulator of gene expression. Despite being extensively studied, how the Polycomb system selects its target genes is poorly understood, and whether its histone-modifying activities are required for transcriptional repression remains controversial. Here, we...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2019.12.001
更新日期:2020-02-20 00:00:00
abstract::We have identified ARAP1 and ARAP2 and examined ARAP1 as a possible link between phosphoinositide-, Arf-, and Rho-mediated cell signaling. ARAP1 contains Arf GAP, Rho GAP, Ankyrin repeat, Ras-associating, and five PH domains. In vitro, ARAP1 had Rho GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent A...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00428-8
更新日期:2002-01-01 00:00:00
abstract::DNA replication is initiated by assembly of the kinase cell division cycle 7 (CDC7) with its regulatory activation subunit, activator of S-phase kinase (ASK), to activate DNA helicase. However, the mechanism underlying regulation of CDC7-ASK complex is unclear. Here, we show that ADP generated from CDC7-mediated MCM p...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.09.007
更新日期:2018-11-15 00:00:00
abstract::Metazoan histone mRNAs end in a highly conserved stem-loop structure followed by ACCCA. Previous studies have suggested that the stem-loop binding protein (SLBP) is the only protein binding this region. Using RNA affinity purification, we identified a second protein, designated 3'hExo, that contains a SAP and a 3' exo...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00278-8
更新日期:2003-08-01 00:00:00
abstract::Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018) reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein disl...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2017.12.031
更新日期:2018-01-18 00:00:00
abstract::Group II intron RNPs are mobile genetic elements that attack and invade duplex DNA. In this work, we monitor the invasion reaction in vitro and establish a quantitative kinetic framework for the steps of this complex cascade. We find that target site specificity is achieved after DNA binding, which occurs nonspecifica...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00069-8
更新日期:2003-03-01 00:00:00
abstract::Autophagy constitutes a prominent mechanism through which eukaryotic cells preserve homeostasis in baseline conditions and in response to perturbations of the intracellular or extracellular microenvironment. Autophagic responses can be relatively non-selective or target a specific subcellular compartment. At least in ...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2015.07.021
更新日期:2015-08-20 00:00:00
abstract::In bacteria, Hfq is a core RNA chaperone that catalyzes the interaction of mRNAs with regulatory small RNAs (sRNAs). To determine in vivo RNA sequence requirements for Hfq interactions, and to study riboregulation in a bacterial pathogen, Hfq was UV crosslinked to RNAs in enterohemorrhagic Escherichia coli (EHEC). Hfq...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2014.05.006
更新日期:2014-07-17 00:00:00
abstract::Autophagic turnover of intracellular constituents is critical for cellular housekeeping, nutrient recycling, and various aspects of growth and development in eukaryotes. Here we show that autophagy impacts the other major degradative route involving the ubiquitin-proteasome system by eliminating 26S proteasomes, a pro...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.04.023
更新日期:2015-06-18 00:00:00
abstract::MicroRNAs (miRNAs) play a pivotal role in the regulation of genes involved in diverse processes such as development, differentiation, and cellular growth control. Recently, many viral-encoded miRNAs have been discovered, for the most part in viruses transcribed from double-stranded DNA genomes. As with their cellular ...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2005.09.012
更新日期:2005-10-07 00:00:00
abstract::The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize ER-mitochondrial contact sites and monitor the localized [Ca(2+)] changes ([Ca(2+)](ER-mt)) using drug-inducible fluorescent interorg...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.06.029
更新日期:2010-07-09 00:00:00
abstract::To map the genomic interaction sites of chromatin proteins, two related methods were developed and experimentally explored in Saccharomyces cerevisiae. The ChIC method (chromatin immunocleavage) consists of tethering a fusion protein (pA-MN) consisting of micrococcal nuclease (MN) and staphylococcal protein A to speci...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.09.007
更新日期:2004-10-08 00:00:00
abstract::Kong et al. (2020) present the low-resolution structure of the ATPɣS-bound human condensin I and II complexes and demonstrate that human condensins can extrude DNA loops in a symmetric and asymmetric fashion and compact nucleosome-bound DNA. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2020.06.025
更新日期:2020-07-02 00:00:00
abstract::Superfamily ATPases in type IV pili, type 2 secretion, and archaella (formerly archaeal flagella) employ similar sequences for distinct biological processes. Here, we structurally and functionally characterize prototypical superfamily ATPase FlaI in Sulfolobus acidocaldarius, showing FlaI activities in archaeal swimmi...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.01.014
更新日期:2013-03-28 00:00:00
abstract::Mitochondrial protein import stress compromises functioning of the organelles, due to inadequate supply of inner mitochondrial proteins. Weidberg and Amon (2018) describe a new monitoring pathway in budding yeast, which restores mitochondrial function following the clearing of accumulated unfolded pre-transported mito...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2018.06.027
更新日期:2018-07-05 00:00:00
abstract::Checkpoint proteins respond to DNA damage by halting the cell cycle until the damage is repaired. In this issue of Molecular Cell, Furuya et al. (2010) provide evidence that checkpoint proteins need to be removed from sites of damage in order to properly repair it. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.11.015
更新日期:2010-11-24 00:00:00
abstract::Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elusive. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.09.040
更新日期:2009-11-25 00:00:00