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A 3' exonuclease that specifically interacts with the 3' end of histone mRNA.

Abstract：

:Metazoan histone mRNAs end in a highly conserved stem-loop structure followed by ACCCA. Previous studies have suggested that the stem-loop binding protein (SLBP) is the only protein binding this region. Using RNA affinity purification, we identified a second protein, designated 3'hExo, that contains a SAP and a 3' exonuclease domain and binds the same sequence. Strikingly, 3'hExo can bind the stem-loop region both separately and simultaneously with SLBP. Binding of 3'hExo requires the terminal ACCCA, whereas binding of SLBP requires the 5' side of the stem-loop region. Recombinant 3'hExo degrades RNA substrates in a 3'-5' direction and has the highest activity toward the wild-type histone mRNA. Binding of SLBP to the stem-loop at the 3' end of RNA prevents its degradation by 3'hExo. These features make 3'hExo a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Dominski Z,Yang XC,Kaygun H,Dadlez M,Marzluff WF

doi

10.1016/s1097-2765(03)00278-8

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

295-305

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(03)00278-8

journal_volume

12

pub_type

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