Abstract:
PURPOSE:To evaluate the association between keratoconus (KC) and immune disorders (IDs). METHODS:A retrospective observational case-control study of all the members in the Central District of Clalit Health Services in Israel who were diagnosed to have KC (years 2000-2007; n = 426) and 1704 age- and gender-matched controls. We calculated the prevalence of the following IDs: rheumatoid arthritis, ulcerative colitis, arthropathy, amyloidosis, systemic lupus erythematosus, celiac disease, multiple sclerosis, myasthenia gravis, polymyalgia rheumatica, idiopathic thrombocytopenic purpura, Crohn disease, Hashimoto thyroiditis, autoimmune hepatitis, irritable bowel syndrome, asthma, and environmental allergy. The odds ratio (OR) of having IDs among patients with KC was compared with controls. RESULTS:The association between KC and the following IDs was statistically significant: rheumatoid arthritis [OR = 8.1; 95% (confidence interval) CI: 1.5-44.2], ulcerative colitis (OR = 12.1; CI: 1.3-116), autoimmune chronic active hepatitis (OR = 6; CI: 1.01-36), Hashimoto thyroiditis (OR = 2.0; CI: 1.2-3.3), arthropathy (OR = 1.4; CI: 1.1-1.8), asthma (OR = 2.1; CI: 1.4-3.2), environmental allergy (OR = 1.3; CI: 1.02-1.75), and irritable bowel syndrome (OR = 5; CI: 2.1-12.1). Two autoimmune diseases, multiple sclerosis (OR = 2; CI: 0.2-22) and Crohn disease (OR = 1.6; CI: 0.3-8.3), were more prevalent among patients with KC but did not reach statistical significance. CONCLUSION:Some strong associations between KC and several immune conditions of autoimmune diseases and allergic IDs may point to the role of the immune system in the pathogenesis of KC.
journal_name
Corneajournal_title
Corneaauthors
Nemet AY,Vinker S,Bahar I,Kaiserman Idoi
10.1097/ICO.0b013e3181cb410bsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
1261-4issue
11eissn
0277-3740issn
1536-4798journal_volume
29pub_type
杂志文章相关文献
CORNEA文献大全abstract::A serial study was carried out with the scanning electron microscope every 5 h to examine the endothelial alterations that occur when the rabbit cornea remains in the eye after enucleation. The findings are compared with those encountered when the cornea with a scleral rim was removed from the globe immediately after ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:Using CJLAT, a chimeric herpes simplex virus (HSV-1) that produces a high incidence of herpes stromal keratitis (HSK) in latently infected rabbits, and in vivo confocal microscopy (CM), we characterized the cellular events that precede the development of HSK. METHODS:Thirty days after infection, in vivo CM was...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000666
更新日期:2016-01-01 00:00:00
abstract::Epithelium plays a very important structural and functional role in the cornea and conjunctiva. Evaluation of the epithelium is the first step in diagnosing many pathologic states. We have developed a new technique for the in vivo staining of nuclei of corneal and conjunctival epithelium in rabbits and guinea pigs. Se...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Here we report a new method for image analysis of the corneal stroma. To obtain the biometric characteristics of a given area, we perform three different treatments of the same image. These automated predictions closely match each parameter (length, surface area, etc.), as measured manually by a "blind investigator." ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199107000-00009
更新日期:1991-07-01 00:00:00
abstract::Two patients developed graft versus host disease (GvHD) following allogeneic bone marrow transplantation for leukemia. One patient developed acute GvHD 12 days after transplantation, and the second developed chronic GvHD 100 days after transplantation. Tear analysis and conjunctival impression cytology were performed....
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The purpose of this study was to evaluate clinical ocular adenoviral isolates for differences among and within serotypes with respect to in vitro infectivity titers and clinical course. The study design included a retrospective chart review and the determination of in vitro infectivity titers (TCID90s) of 90 clinical ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199507000-00007
更新日期:1995-07-01 00:00:00
abstract:PURPOSE:To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema. METHODS:Case report. RESULTS:We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative d...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318041f0c0
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:Sequential therapeutic penetrating keratoplasty (TPK) using a cryopreserved cornea followed soon after by a fresh optical grade cornea for severe infectious keratitis may improve the survival of the optical graft. The aim of this study was to compare the therapeutic efficacy, visual outcomes, and graft survival...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318203217c
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To review ocular injuries secondary to airbag deployment that were seen in our institution and were reported in the literature. METHODS:Patients examined at our institution between 1997 and 2000 were evaluated for ocular injuries caused by airbags. A review of the medical literature using Medline was performed...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/00003226-200103000-00009
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To compare the survival rate 1 year after Descemet membrane endothelial keratoplasty (DMEK) in pseudophakic eyes versus combined phacoemulsification and DMEK (triple-DMEK). METHODS:Retrospective, interventional, consecutive case series. From all DMEKs performed from January 1, 2017, to June 30, 2018, we select...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002636
更新日期:2020-12-22 00:00:00
abstract:PURPOSE:To report our experience in the treatment of intraepithelial neoplasia of the conjunctiva using topical bevacizumab. METHODS:Ten eyes of 10 patients with conjunctival neoplasia received 25 mg/mL bevacizumab topically. Changes in the lesions were documented weekly using digital photography. After topical treatm...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000194
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To report a case of Listeria monocytogenes sclerokeratitis and to review the literature. METHODS:Case report. RESULTS:A 25-year-old non-contact lens-wearing male rugby player was referred with progressive infective sclerokeratitis unresponsive to topical antivirals and antibiotics. On examination, visual acui...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31816c4078
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To establish determining factors for fast corneal sensitivity (CS) recovery after pterygium excision. METHODS:Thirty-two eyes of 14 males and 18 females with primary nasal pterygium were recruited. Differences in CS (in the 4 quadrants and the center using a Cochet-Bonnet esthesiometer), pterygium corneal area...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000932
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the psychometric properties of the Keratoconus Outcomes Research Questionnaire (KORQ) in patients enrolled in the Save Sight Keratoconus Registry. METHODS:A cross-sectional study was conducted utilizing prospectively collected web-based registry data. The psychometric prop...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002169
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To describe an invasive spindle cell carcinoma of the conjunctiva managed by full-thickness eye wall resection. METHODS:A 51-year-old man developed a conjunctival mass that was excised and proved to be a spindle cell carcinoma. A tumor recurrence 20 months later was evaluated by ultrasound biomicroscopy (UBM) ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3180cfe80e
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To describe 3-dimensional optical coherence tomography (OCT) findings in a case of granular corneal dystrophy. METHODS:A 1310-nm high-speed swept-source OCT prototype was used to image the 3-dimensional structures of the cornea of a patient with granular corneal dystrophy. RESULTS:Three-dimensional OCT clearl...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31802e1e50
更新日期:2007-04-01 00:00:00
abstract::Vitamin A deficiency causing xerophthalmia, although a major public health issue in sub-Saharan Africa, is rarely seen in people living in developed countries. In such cases, it is usually associated with severe malnutrition caused by intestinal disorders, such as celiac disease, pancreatitis, or extensive bowel surge...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181bd9ed5
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To evaluate endothelial cell damage after eye bank preparation and passage through 1 of 2 different injectors for Descemet membrane endothelial keratoplasty grafts. METHODS:Eighteen Descemet membrane endothelial keratoplasty grafts were prepared by Lions VisionGift with the standard partial prepeel technique a...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000690
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:We report a case of mycotic keratitis caused by a rare fungus Chaetomium atrobrunneum. METHODS:Clinical examination, slit-lamp examination, and microbiological evaluation of corneal ulcer were done, and its treatment outcome was studied. The fungal etiology was established by conventional microbiological techn...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31821eeaed
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To describe a case of conjunctival malignant melanoma associated with pseudomelanomatous alteration of the apposing tarsal conjunctiva. METHODS:A 93-year-old woman presented with an elevated, pigmented mass on her superior bulbar conjunctiva. The tumor was associated with increased pigmentation of the apposing...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000226358.26678.98
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:To describe a case of transient band-like keratopathy after ocular exposure to fluocinonide cream and ketoconazole shampoo. DESIGN:Observational case report. RESULTS:A 40-year-old patient presented with acute pain, photophobia, lacrimation, and redness in 1 eye. The symptoms began while using fluocinonide cre...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000138854.33956.3d
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:To identify potential donor, recipient, surgical, and postoperative factors that may influence survival and visual outcome of penetrating keratoplasty (PKP). METHODS:As part of a prospective longitudinal study, the electronic records of the New Zealand National Eye Bank were analyzed for the 10-year period fro...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3182014668
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To compare the endothelial cell damage after lens removal using a fluid-based system to conventional ultrasound. METHODS:Twenty human cadaver eyes were randomized to undergo phacoemulsification using either a fluid-based system or conventional ultrasound. After surgery, each corneoscleral button was removed, s...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000130184.56514.51
更新日期:2004-10-01 00:00:00
abstract:PURPOSE:To determine whether a combination of early amniotic membrane transplantation (AMT) and early topical corticosteroid treatment could be a safe adjuvant therapy during antibacterial treatment in severe bacterial keratitis (BK) for relieving pain, avoiding iatrogenic epithelial toxicity, and allowing earlier use ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31802b28df
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of ultraviolet-corneal cross-linking (CXL) for treating infectious melting keratitis. METHODS:Five patients with infectious keratitis associated with corneal melting were treated with CXL at the outpatient departments of the Institut für Refraktive und Ophthalmo-Chirurgie and the eye h...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318169d698
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To evaluate tear meniscus changes in patients with Sjögren syndrome (SS) receiving oral pilocarpine with Visante optical coherence tomography (OCT). METHODS:Eight patients with primary SS were recruited in this prospective interventional case series study. Patients received pilocarpine tablets twice a day for ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318261eb4a
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To compare the effects of levobunolol hydrochloride and timolol maleate on tear volume, precorneal tear film stability, and corneal epithelial barrier function in normal human eyes. SUBJECTS AND METHODS:The study population consisted of 14 healthy volunteers. To obtain pretreatment baseline values, we determin...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200311000-00001
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:To report a case of Alternaria alternata keratitis analyzed with in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (OCT). METHODS:A 68-year-old man with unilateral keratitis was evaluated using IVCM (Heidelberg Retina Tomograph II; Heidelberg, Germany) and anterior segment OC...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181dae1f3
更新日期:2011-04-01 00:00:00
abstract:PURPOSE:To study the expression of toll-like receptors (TLRs) in healthy corneas and corneas with active or nonactive herpetic stromal keratitis (HSK). METHODS:Eight corneas with HSK (including 5 active and 3 nonactive cases) and 8 healthy corneas were evaluated for TLR1-10 mRNA by reverse transcription-polymerase cha...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e318093de1f
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To report the indications, long-term structural and functional outcomes, and prognostic factors for the success of penetrating and lamellar corneal patch grafts. METHODS:This is a retrospective analysis of 49 patients who underwent the corneal patch graft procedure over 8 years. The baseline, preoperative, and...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002529
更新日期:2020-09-29 00:00:00