Abstract：
:Invadopodia are actin-rich, adhesive protrusions that extend into and remodel the extracellular matrix. They are associated with high levels of pericellular proteolysis and correlate with the invasive capacity of a variety of tumour cells. Invadopodia have, thus, been proposed to recapitulate key events of the metastatic process. Although our understanding of the patho-physiology of invadopodia is still in its infancy, the molecular components and signalling pathways leading to their formation have received increasing attention. Recent studies have revealed that diverse membrane polarized secretory and endo/exocytic trafficking pathways converge at these structures for the delivery, in a temporally controlled and spatially confined manner, of key proteolytic enzymes. Here, we will focus our attention on MT1-MMP, a paradigmatic metalloprotease that is primarily responsible for the proteolytic activity of invadopodia. We propose that the biosynthetic/secretory pathway might be critical for the polarized delivery of MT1-MMP to invadopodia that form as "default response" whenever cells have to deal with extracellular matrix (ECM) of variable composition and stiffness. Conversely, "inducible" endo/exocytic trafficking routes might primarily control the delivery of MT1-MMP to invadopodia when cells need to respond in a fast and transient manner to soluble motogenic factors, rather than the insoluble ECM.
journal_name
Eur J Cell Bioljournal_title
European journal of cell biologyauthors
Frittoli E,Palamidessi A,Disanza A,Scita Gdoi
10.1016/j.ejcb.2010.04.007subject
Has Abstractpub_date
2011-02-01 00:00:00pages
108-14issue
2-3eissn
0171-9335issn
1618-1298pii
S0171-9335(10)00109-3journal_volume
90pub_type
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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abstract：:Extraovarian estrogen production is localized mainly in stromal vascular cells from adipose tissue, which contain the aromatase activity necessary for the conversion of androgens to estrogens. Induction of aromatase activity in these cells by glucocorticoids occurs only in the presence of a serum factor, the propertie...
journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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更新日期：1980-04-01 00:00:00
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journal_title：European journal of cell biology
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doi：
更新日期：1979-06-01 00:00:00
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
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journal_title：European journal of cell biology
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doi：
更新日期：1997-12-01 00:00:00
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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doi：
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journal_title：European journal of cell biology
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更新日期：1997-03-01 00:00:00
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journal_title：European journal of cell biology
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journal_title：European journal of cell biology
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更新日期：1985-03-01 00:00:00
