Abstract:
INTRODUCTION:The aims of this study were to evaluate whether the antihypertensive effect of garlic could to be associated to interactions with adrenergic and dopaminergic receptors involved in regulating blood pressure and to compare these data with those obtained from wild Allium species. METHODS:The aqueous extracts of bulbs or leaves of Allium sativum L. (garlic), Allium neapolitanum Cyr., Allium subhirsutum L., and Allium roseum L. were tested for their in vitro affinity for the adrenergic (alpha(1), alpha(2), beta(1) and beta(2)) and dopaminergic (D(1) and D(2)) receptors by radioligand binding assays. RESULTS:Interesting results were shown by bulbs extracts of A. neapolitanum and A. subhirsutum with higher affinities for the beta(2) receptors and by bulbs extract of A. roseum for D(2) receptors. CONCLUSIONS:The known antihypertensive activity of Allium sativum cannot be correlated with binding to receptors involved in blood pressure regulation. However, aqueous extracts of the wild-type species of Allium show much higher affinities, warranting further explorations.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Nencini C,Franchi GG,Micheli Ldoi
10.3109/09637481003591608subject
Has Abstractpub_date
2010-06-01 00:00:00pages
433-9issue
4eissn
0963-7486issn
1465-3478journal_volume
61pub_type
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journal_title:International journal of food sciences and nutrition
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