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Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones.

Abstract：

:Resistance to chloroquine (CQ) in Plasmodium falciparum has a major impact on malaria control worldwide. To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (3D7) and CQ-resistant (Dd2) clones under transient IC50 CQ-exposure (Dd2, 200 nM; 3D7, 14 nM). Upon 2-h CQ challenge, the mRNA upregulation detected was greater in 3D7 (six genes overexpressed at 1/3 of the intraerythrocytic cycle) than in Dd2 clone (three genes responding), providing evidence of an early transcriptional response to CQ-induced oxidative stress which might underlie some of the parasite's metabolic adaptation to the drug.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Nogueira F,Diez A,Radfar A,Pérez-Benavente S,do Rosario VE,Puyet A,Bautista JM

doi

10.1016/j.actatropica.2010.01.013

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

109-15

issue

2

eissn

0001-706X

issn

1873-6254

pii

S0001-706X(10)00028-8

journal_volume

114

pub_type

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