Abstract：
:Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gram-negative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82+/-10.90 microM versus 3.86+/-1.34 microM, P < 0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Maciel EA,Athanazio DA,Reis EA,Cunha FQ,Queiroz A,Almeida D,McBride AJ,Ko AI,Reis MGdoi
10.1016/j.actatropica.2006.11.006subject
Has Abstractpub_date
2006-12-01 00:00:00pages
256-60issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(06)00236-1journal_volume
100pub_type
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