Abstract:
:The administration of flurbiprofen, a potent non-steroidal anti-inflammatory drug (NSAID), to goats infected with trypanosomes resulted in high elevated parasitaemia and suppression of fever. In contrast to goats, rats infected with trypanosomes do not show febrile reactions. Therefore, the role of body temperature was investigated with yeast-induced fever in Trypanosoma evansi and T. brucei infected rats. These investigations did not support the hypothesis that a high body temperature causes a drop in parasitaemia. In goats infected with trypanosomes, it is also unlikely that fever has an inhibitory influence on the parasitaemia. In these animals, rises in parasitaemia could be provoked by doses of flurbiprofen as low as 1/20 of the normal doses and these doses did not or only partly suppressed fever. No effect on parasite growth could be obtained when flurbiprofen was added in concentrations up to 32 micrograms/ml directly to T. brucei cultures. Moreover, no growth promoting factor(s) could be identified in vitro in serum from flurbiprofen-treated goats.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Zwart D,Brun R,Dwinger RH,van Miert AS,Franssen FF,Nieuwenhuijs J,Kooy RFdoi
10.1016/0001-706x(90)90073-9subject
Has Abstractpub_date
1990-02-01 00:00:00pages
115-23issue
2eissn
0001-706Xissn
1873-6254pii
0001-706X(90)90073-9journal_volume
47pub_type
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