Influence of fever and flurbiprofen on trypanosome growth.

Abstract:

:The administration of flurbiprofen, a potent non-steroidal anti-inflammatory drug (NSAID), to goats infected with trypanosomes resulted in high elevated parasitaemia and suppression of fever. In contrast to goats, rats infected with trypanosomes do not show febrile reactions. Therefore, the role of body temperature was investigated with yeast-induced fever in Trypanosoma evansi and T. brucei infected rats. These investigations did not support the hypothesis that a high body temperature causes a drop in parasitaemia. In goats infected with trypanosomes, it is also unlikely that fever has an inhibitory influence on the parasitaemia. In these animals, rises in parasitaemia could be provoked by doses of flurbiprofen as low as 1/20 of the normal doses and these doses did not or only partly suppressed fever. No effect on parasite growth could be obtained when flurbiprofen was added in concentrations up to 32 micrograms/ml directly to T. brucei cultures. Moreover, no growth promoting factor(s) could be identified in vitro in serum from flurbiprofen-treated goats.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Zwart D,Brun R,Dwinger RH,van Miert AS,Franssen FF,Nieuwenhuijs J,Kooy RF

doi

10.1016/0001-706x(90)90073-9

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

115-23

issue

2

eissn

0001-706X

issn

1873-6254

pii

0001-706X(90)90073-9

journal_volume

47

pub_type

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