Abstract：
:The persistence of Trypanosoma cruzi in seropositive individuals, previously diagnosed as chronic chagasic patients (CCP), was detected for the first time in biopsies taken from gingival inflammatory foci processed by polymerase chain reaction (PCR). Seven out of 31 (22.5%) gum samples from selected unquestionably CCP showing different degrees of gingival inflammation revealed T. cruzi-DNA using 3 specific PCR assays. All the included CCP had been diagnosed in previous studies carried out over the last 19 years. Samples of inflamed gums were recently taken from the indicated patients at: an outpatient hospital cardiac unit; a village where Chagas disease is endemic; and a specialized diagnostic research center, showing molecular evidence of parasite persistence in 17.6%, 42.8% and 14.3% of them, respectively. The relatively frequent parasite persistence, demonstrated here in oral inflammatory processes of treated and/or untreated patients bearing long term T. cruzi-infection, suggests the establishment of secondary small foci for the maintenance of hidden or inapparent chagasic infection. The easy and low-risk, non-invasive method to get the sample may add the use of gingival biopsy as a potential alternative diagnostic tool to confirm T. cruzi-infection in CCP. The significance of T. cruzi persistence as a primary cause of chronic Chagas disease and the proposal of this mechanism to explain the pathogenesis in CCP are considered.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Añez N,Crisante G,Caraballo F,Delgado W,Parada Hdoi
10.1016/j.actatropica.2010.12.010subject
Has Abstractpub_date
2011-03-01 00:00:00pages
207-11issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(10)00304-9journal_volume
117pub_type
杂志文章相关文献
ACTA TROPICA文献大全abstract：:Extracellular vesicles (EVs) play a key role in host-parasite interactions. Previous studies have shown that parasites can release microRNA (miRNA) containing EVs, which can transfer their contents to host cells and regulate gene expression in recipient cells. However, a little is known about the secretion of EVs by t...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105718
更新日期：2020-12-01 00:00:00
abstract：:Malaria is transmitted by Plasmodium parasites through the bite of female Anopheles mosquitoes. One of the most important mosquito vectors in the Greater Mekong Subregion is Anopheles dirus. This study reports RNA sequencing (RNA-Seq) transcriptome analysis of An. dirus at 18 hours and 7 days after a P. vivax-infected...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2020.105502
更新日期：2020-07-01 00:00:00
abstract：:Extracts prepared from 15 rare Tanzanian medicinal plants were tested for their in vitro antitrypanosomal activity against human pathogenic trypanosomes (Trypanosoma brucei rhodesiense). Of 37 extracts investigated, two were found to have strong activity with IC50 values below 1 microgram/ml and ten extracts revealed ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(97)00034-x
更新日期：1997-08-01 00:00:00
abstract：:Toxoplasmosis is caused by the protozoon Toxoplasma gondii that can infect almost all warm-blooded hosts including horses and humans. Horse meat is one of the most important meat products for human consumption. However, data on seroprevalence of T. gondii in horses intended for human consumption in Northern China is s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.07.030
更新日期：2018-11-01 00:00:00
abstract：:The preference of Triatoma infestans for shelters at different temperatures or relative humidities (RH) was tested in laboratory assays. The insects preferred refuges at a temperature of 34 degrees C rather than 26 degrees C, and chose to stay in refuges with an RH of 20% rather than 80%. Temperature and RH records ma...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(98)00094-1
更新日期：1999-04-30 00:00:00
abstract：:Echinococcosis, a disease caused by infection with the larval stage of a tapeworm parasite of the genus Echinococcus, is of major socio-economic importance, and studying genetic variability within and between Echinococcus populations has important implications for disease control and epidemiology. Various DNA approach...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(98)00052-7
更新日期：1998-09-15 00:00:00
abstract：:Immune sera obtained from either BALB/c mice (susceptible) at 7 weeks, or C57BL/6 mice (resistant), at 7 weeks after infection with L. m. amazonensis, were effective in increasing internalization of homologous promastigotes into starch-induced peritoneal macrophages (from both mouse strains). Both the internalization ...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1987-09-01 00:00:00
abstract：:Triatoma williami is naturally infected by Trypanosoma cruzi, the ethiological agent of Chagas disease, the most significant cause of morbidity and mortality in South and Central America.The possibility of domiciliation of T. williami increases the risk of human T. cruzi vetorial transmission. Despite this, there is a...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2015.05.023
更新日期：2015-09-01 00:00:00
abstract：:Plasmodium vivax merozoite surface protein 1 (PvMSP-1) is a leading malaria vaccine candidate. This protein is processed to give rise to various sized fragments during merozoite maturation. Here, we describe the analysis of genetic diversity in the 42 kDa C-terminal part of this protein among 33 Indian P. vivax isolat...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2008.08.011
更新日期：2008-10-01 00:00:00
abstract：:Although long considered a non-pathogenic protozoan, Giardia lamblia is now a well recognized cause of abdominal discomfort, diarrhoea and failure-to-thrive in children. The overall prevalence of this infection in Cuban population is about 7.2%; however, higher prevalences have been found among young children attendin...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2011.04.014
更新日期：2011-08-01 00:00:00
abstract：:As the only specialized institution for research and control of parasitic diseases at the national level in China for almost 70 years, the National Institute of Parasitic Diseases (NIPD) at the Chinese Center for Disease Control and Prevention (China CDC) has been instrumental in supporting the remarkable progress fro...
journal_title：Acta tropica
pub_type： 杂志文章,评审
doi：10.1016/j.actatropica.2019.105219
更新日期：2020-01-01 00:00:00
abstract：:Two PCR methods were compared for their sensitivity in detecting cultured Leishmania major, before being used to estimate infection rates in female sandflies (Phlebotomus papatasi) collected from peridomestic animal shelters and the nearby burrows of the gerbil reservoir hosts, Rhombomys opimus, in Isfahan province, c...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2004.09.007
更新日期：2005-01-01 00:00:00
abstract：:Human cystic echinococcosis (CE) has been considered to be caused predominantly by Echinococcus granulosus sensu stricto (the dog-sheep strain). Molecular approaches on CE, however, have revealed that human cases are also commonly caused by another species, Echinococcus canadensis. All indices for classification and s...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.05.013
更新日期：2017-01-01 00:00:00
abstract：:The aim of this study is to investigate the feasibility and outcomes of using Gravid Oviposition Sticky (GOS) trap and dengue NS1 antigen tests for indoor and outdoor dengue/Aedes surveillance in the field. A one-year community-based study was carried out at Sungai Buloh Hospital Quarters, Selangor, Malaysia. GOS trap...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2021.105829
更新日期：2021-01-16 00:00:00
abstract：:The critical step of Trichinella spiralis infection is that the muscle larvae (ML) are activated to intestinal infective larvae (IIL) which invade the intestinal columnar epithelium to further develop. The IIL excretory/secretory (ES) proteins play an important role in host-parasite interaction. Proteolytic enzymes ar...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2021.105825
更新日期：2021-01-07 00:00:00
abstract：:The World Health Organization (WHO) treatment protocols for cystic echinococcosis (CE) are based on the standardized ultrasound (US) classification. This study examined whether the classification reflected the natural history of CE in untreated and albendazole-treated patients. Data were collected during mass US scree...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.03.018
更新日期：2017-07-01 00:00:00
abstract：:A randomized double-blind study was performed to compare the side effects of long-term chemoprophylaxis of malaria with Fansidar (1 tablet a week) with those of a 300-mg weekly chloroquine regimen. This study was designed as a field trial with Austrian industrial workers in Nigeria and included 173 volunteers, 86 taki...
journal_title：Acta tropica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-12-01 00:00:00
abstract：:We evaluated the use of polymerase chain reaction (PCR) for diagnosis of mucosal leishmaniasis (ML) in an endemic area in Acre, Brazil, where Leishmania braziliensis is present. Leishmania DNA was detected 34 of 35 cases, yielding a positivity rate of 97.1%, which was higher than the positivity rates for all of the ot...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2004.12.003
更新日期：2005-04-01 00:00:00
abstract：:Heartwater caused by Ehrlichia ruminantiumis a disease of domestic and wild ruminants and one of the most economically important tick-borne diseases in Africa. The present study aimed to investigate the occurrence and genetic diversity of E. ruminantium in blood samples from 210 cattle sampled in five districts of Map...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2019.01.007
更新日期：2019-03-01 00:00:00
abstract：:In developing countries, smallholder poultry production contributes to food security and poverty alleviation in rural areas. However, traditional poultry marketing chains have been threatened by the epidemics caused by the Highly Pathogenic Avian Influenza (H5N1) virus. The article presents a value chain analysis cond...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2013.01.008
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Cystic echinococcosis (CE) is a zoonotic disease that presents a public health challenge and a socioeconomic burden on developing areas in the Middle East. This study used spatial methods to assess the distribution of surgically managed CE cases in an endemic region of north-eastern Iran. METHODS:For the ye...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2016.08.003
更新日期：2016-11-01 00:00:00
abstract：:Giardiasis is an intestinal parasitosis that affects millions of people worldwide and is considered a zoonotic disease. Frequently in contact with humans, dogs are the main host involved in this zoonotic transmission. Here, we compared some aspects of Giardia duodenalis biology between two strains: a recently isolated...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:China was once a country plagued by parasitic diseases. At the beginning of the founding of the People's Republic of China, nearly 80% of the population suffered from parasitic diseases because of poverty and poor sanitary conditions. After nearly 70 years of development, China has made remarkable achievements in the ...
journal_title：Acta tropica
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.actatropica.2019.105181
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Dengue incidence has grown dramatically around the world in recent years. Vector control is the only method to reduce dengue incidence due to the lack of a vaccine available. By understanding the factors contributed to the vector densities such as environmental and sociological factors, dengue prevention and...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2021.105834
更新日期：2021-01-21 00:00:00
abstract：:In the present investigation, it has been demonstrated that cattle become resistant to ticks after several heavy infestations, particularly with B. microplus. During development of the infestations, antibodies against salivary glands of B. microplus were detected using 2 techniques: indirect immunofluorescence and imm...
journal_title：Acta tropica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The in vitro metacyclogenesis of a visceral (VL) and cutaneous (CL) human strain of Leishmania infantum was monitored in order to find out the kinetics of this process and the in vitro infective capacity for macrophages of the metacyclic promastigotes developed. To identify, enumerate, and separate the metacyclic popu...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/s0001-706x(98)00041-2
更新日期：1998-07-30 00:00:00
abstract：:Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P. vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the pvmdr1 and pvcrt-o genes, and the copy number of...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2010.08.011
更新日期：2011-02-01 00:00:00
abstract：:Transmission risk for vector borne disease is greatest during periods of heightened vector activity. Triatomine bugs (Hemiptera: Reduviidae), which transmit Trypanosoma cruzi, the causative agent of Chagas disease, are generally considered nocturnal, but their patterns of activity in controlled settings have rarely be...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.06.012
更新日期：2018-09-01 00:00:00
abstract：:The rat lungworm Angiostrongylus cantonensis causes human eosinophilic meningitis and it is endemic in Southeast Asia, but little is known about its distribution in Laos, Cambodia and Vietnam. We conducted a multi-country survey for A. cantonensis in these countries to estimate its prevalence in snails along the Mekon...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2018.03.021
更新日期：2018-07-01 00:00:00
abstract：:In 2009, a survey was conducted in Reunion Island to determine the renal leptospiral load in black rats trapped in the field. The concentration of leptospires in kidney tissue was calculated using qPCR. Our results showed high inter-individual variations of renal bacterial load in naturally infected black rats (mean=8...
journal_title：Acta tropica
pub_type： 杂志文章
doi：10.1016/j.actatropica.2012.11.011
更新日期：2013-03-01 00:00:00
