Abstract：
:In the presence of light and oxygen, rose bengal causes oxidative damage to Trypanosoma cruzi. The production of lipid hydroperoxides was demonstrated by thin-layer chromatography, and severe ultrastructural alterations compatible with an increased permeability of the cells, which led to gradual osmotic swelling and ultimately to lysis, were observed by electron microscopy. As a result of this treatment, the infectivity of T. cruzi trypomastigotes in mice was abolished. In addition, under anaerobic conditions, rose bengal was found to undergo a one-electron reduction in intact T. cruzi epimastigotes to produce a carbon-centered free radical as demonstrated by electron spin resonance spectroscopy. The formation of this radical was also enhanced by light.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Cruz FS,Lopes LA,De Souza W,Moreno SN,Mason RP,Docampo Rsubject
Has Abstractpub_date
1984-06-01 00:00:00pages
99-108issue
2eissn
0001-706Xissn
1873-6254journal_volume
41pub_type
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