Abstract：
:The murine monoclonal anti-idiotypic antibody NP30 is a promising therapeutic antibody against Schistosoma japonicum. However, the immunogenicity of murine NP30 limits its further study and application in humans. Here the chimeric Fab of NP30 (chFab-NP30) comprising the variable regions of murine NP30 and constant regions of human antibody was assembled. chFab-NP30 was expressed and purified as a soluble and functional protein. Administration of chFab-NP30 in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. Our study indicated that chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica. Further studies on function mechanism of chFab-NP30 needs to be carried out in the future.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Xu J,Zhu XJ,Li YH,Dai Y,Zhu YC,Zheng J,Feng ZQ,Guan XHdoi
10.1016/j.actatropica.2011.01.006subject
Has Abstractpub_date
2011-05-01 00:00:00pages
159-64issue
2eissn
0001-706Xissn
1873-6254pii
S0001-706X(11)00007-6journal_volume
118pub_type
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