Abstract：
:This study provides the first estimate of the genetic diversity and genotype multiplicity of Plasmodium falciparum infections in symptomatic individuals living in Bangui (Central African Republic, CAR). Three hundred thirty six clinical isolates were used for analysis of parasite population polymorphism and genotyped by nested-PCR of msp-1 block 2, and msp-2 block 3. We found a very high level of polymorphism, with, respectively, 17 and 25 different alleles at the msp-1 and msp-2 loci and a high percentage of multiclonal infections (42.7% with msp-1 and 76.7% with msp-2), with a mean of 1.7 genotype with msp-1 and 2.8 with msp-2. We observed that (i) multiclonal infections and allelic polymorphism of msp-2 were significantly more frequent in Southern districts than in Northern districts of Bangui suggesting that the epidemiological features of P. falciparum may vary within Bangui and (ii) showed that immunocompromised HIV-positive patients tend to have a lower average number of msp-2 allele per isolate than immunocompetent patients.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Dolmazon V,Matsika-Claquin MD,Manirakiza A,Yapou F,Nambot M,Menard Ddoi
10.1016/j.actatropica.2008.04.012subject
Has Abstractpub_date
2008-07-01 00:00:00pages
37-42issue
1eissn
0001-706Xissn
1873-6254pii
S0001-706X(08)00096-Xjournal_volume
107pub_type
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