Abstract：
:With the paradigm shift from the reduction of morbidity and mortality to the interruption of transmission, the focus of malaria control broadens from symptomatic infections in children ≤5 years of age to include asymptomatic infections in older children and adults. In addition, as control efforts intensify and the number of interventions increases, there will be decreases in prevalence, incidence and transmission with additional decreases in morbidity and mortality. Expected secondary consequences of these changes include upward shifts in the peak ages for infection (parasitemia) and disease, increases in the ages for acquisition of antiparasite humoral and cellular immune responses and increases in false-negative blood smears and rapid diagnostic tests. Strategies to monitor these changes must include: (1) studies of the entire population (that are not restricted to children ≤5 or ≤10 years of age), (2) study sites in both cities and rural areas (because of increasing urbanization across sub-Saharan Africa) and (3) innovative strategies for surveillance as the prevalence of infection decreases and the frequency of false-negative smears and rapid diagnostic tests increases.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Doumbia SO,Ndiaye D,Koita OA,Diakité M,Nwakanma D,Coulibaly M,Traoré SF,Keating J,Milner DA Jr,Ndiaye JL,Sene PD,Ahouidi A,Dieye TN,Gaye O,Okebe J,Ceesay SJ,Ngwa A,Oriero EC,Konaté L,Sy N,Jawara M,Faye O,Kéitadoi
10.1016/j.actatropica.2011.11.009subject
Has Abstractpub_date
2012-03-01 00:00:00pages
175-83issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(11)00335-4journal_volume
121pub_type
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