Abstract：
:We conducted the first meta-analysis of ten Schistosoma haematobium (one published and nine unpublished) and eight Schistosoma mansoni (two published and six unpublished) microsatellite datasets collected from individual schistosome-infected school-children across six sub-Saharan Africa countries. High levels of genetic diversity were documented in both S. haematobium and S. mansoni. In S. haematobium populations, allelic richness did not differ significantly between the ten schools, despite widely varying prevalences and intensities of infection, but higher levels of heterozygote deficiency were seen in East than in West Africa. In contrast, S. mansoni populations were more diverse in East than West African schools, but heterozygosity levels did not vary significantly with geography. Genetic structure in both S. haematobium and S. mansoni populations was documented, at both a regional and continental scale. Such structuring might be expected to slow the spread to new areas of anti-schistosomal drug resistance should it develop. There was, however, limited evidence of genetic structure at the individual host level, which might be predicted to promote the development or establishment of drug resistance, particularly if it were a recessive trait. Our results are discussed in terms of their potential implications for the epidemiology and evolution of schistosomes as well as their subsequent control across sub-Saharan Africa.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Gower CM,Gouvras AN,Lamberton PH,Deol A,Shrivastava J,Mutombo PN,Mbuh JV,Norton AJ,Webster BL,Stothard JR,Garba A,Lamine MS,Kariuki C,Lange CN,Mkoji GM,Kabatereine NB,Gabrielli AF,Rudge JW,Fenwick A,Sacko M,Dembeldoi
10.1016/j.actatropica.2012.09.014subject
Has Abstractpub_date
2013-11-01 00:00:00pages
261-74issue
2eissn
0001-706Xissn
1873-6254pii
S0001-706X(12)00333-6journal_volume
128pub_type
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