Abstract：
:Strongyloidiasis is widely distributed in the tropical and subtropical areas. Ivermectin is the drug of choice for the treatment. However, the concerns about relying treatment on a single drug make identification of new molecules a priority. Alkylphospholipid analogues, including edelfosine, are a group of synthetic compounds that have shown activity against some parasites. The objective was to assess the in vitro and in vivo activity of edelfosine, miltefosine, perifosine against Strongyloides venezuelensis. Moreover, apoptosis-like mechanism in larvae after treatment was studied. Edelfosine displayed the highest activity and the best selectivity index (LD50=49.6 ± 5.4μM, SI=1.1) compared to miltefosine or perifosine. Third stage larvae after culture with edelfosine were not able to develop an infection in mice. Treatment of mice with edelfosine showed reduction of 47% in parasitic females allocated in the gut. Moreover, DNA fragmentation was observed by TUNEL staining in larvae treated with edelfosine. These results suggest that edelfosine could be an effective drug against strongyloidiasis, probably through induction of apoptosis-like cell death.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Legarda-Ceballos AL,Rojas-Caraballo J,López-Abán J,Ruano AL,Yepes E,Gajate C,Mollinedo F,Muro Adoi
10.1016/j.actatropica.2016.07.001subject
Has Abstractpub_date
2016-10-01 00:00:00pages
180-187eissn
0001-706Xissn
1873-6254pii
S0001-706X(16)30460-0journal_volume
162pub_type
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