Abstract：
:The insect molting hormone and related compounds (ecdysteroids) have been found in patients infected with helminths. To investigate this phenomenon, we quantified and analyzed the urinary ecdysteroids in Malian subjects suffering from various helminthiases, as well as in Europeans. Very high titers (up to 100 nM) were found in some patients, whereas healthy persons had a basic level of 4 nM only. The high RIA activity was mainly due to two compounds. One of them was remarkable for being present in all the positive samples; it comigrated with the 20-hydroxyecdysone standard, both in HPLC and in TLC. The origin and the physiological significance of these compounds are questionable, since there was no clear relationship between their levels and the severity of the diseases. Numerous patients who were heavily infected had normal titers. Nevertheless, there is no doubt that high concentrations of ecdysteroid-like compounds in human urine indicate a pathological condition.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Baswaïd S,Gharib B,Doumbo O,Quilici M,de Reggi Mdoi
10.1016/0001-706x(90)90009-osubject
Has Abstractpub_date
1990-05-01 00:00:00pages
197-204issue
4eissn
0001-706Xissn
1873-6254pii
0001-706X(90)90009-Ojournal_volume
47pub_type
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