Abstract：
:Sm14 and paramyosin are two major Schistosoma mansoni vaccine candidate antigens. Recently, we have identified Sm14 and paramyosin epitopes that are recognized by T cells of resistant individuals living in endemic areas for schistosomiasis. Herein, mice were immunized with these peptides separately or in association in order to evaluate their vaccine potential. Immunization of mice with Sm14 peptides alone or mixed with paramyosin peptides was able to induce 26%-36.7% or 28%-29.2% of worm burden reduction, 67% or 46% of intestinal eggs reduction and also 54%-61% or 43%-52% of liver pathology reduction, respectively. Protection was associated with a Th1 type of immune response induced by Sm14 peptide immunization. In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response.
journal_name
Acta Tropjournal_title
Acta tropicaauthors
Garcia TC,Fonseca CT,Pacifico LG,Durães Fdo V,Marinho FA,Penido ML,Caliari MV,de Melo AL,Pinto HA,Barsante MM,Cunha-Neto E,Oliveira SCdoi
10.1016/j.actatropica.2008.03.003subject
Has Abstractpub_date
2008-06-01 00:00:00pages
162-7issue
3eissn
0001-706Xissn
1873-6254pii
S0001-706X(08)00072-7journal_volume
106pub_type
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