Whole-genome sequence analysis and exploration of the zoonotic potential of a rat-borne Bartonella elizabethae.

Abstract:

:Bartonella elizabethae has been known to cause endocarditis and neuroretinitis in humans. The genomic features and virulence profiles of a B. elizabethae strain (designated as BeUM) isolated from the spleen of a wild rat in Kuala Lumpur, Malaysia are described in this study. The BeUM strain has a genome size of 1,932,479bp and GC content of 38.3%. There is a high degree of conservation between the genomes of strain BeUM with B. elizabethae type strains (ATCC 49927 and F9251) and a rat-borne strain, Re6043vi. Of 2137 gene clusters identified from B. elizabethae strains, 2064 (96.6%) are indicated as the core gene clusters. Comparative genome analysis of B. elizabethae strains reveals virulence genes which are known in other pathogenic Bartonella species, including VirB2-11, vbhB2-B11, VirD4, trw, vapA2-5, hbpA-E, bepA-F, bepH, badA/vomp/brp, ialB, omp43/89 and korA-B. A putative intact prophage has been identified in the strain BeUM, in addition to a 8kb pathogenicity island. The whole genome analysis supports the zoonotic potential of the rodent-borne B. elizabethae, and provides basis for future functional and pathogenicity studies of B. elizabethae.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Tay ST,Kho KL,Wee WY,Choo SW

doi

10.1016/j.actatropica.2015.11.019

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

25-33

eissn

0001-706X

issn

1873-6254

pii

S0001-706X(15)30167-4

journal_volume

155

pub_type

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