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Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis.

Abstract：

:The several steps in the pathway for the biosynthesis of fibrillar collagen are reviewed to illustrate potential sites for the chemotherapeutic control of fibrosis. Particular emphasis is placed upon the properties and inhibition of lysyl oxidase, the enzyme which initiates the covalent crosslinking of extracellular collagen molecules converting these to insoluble fibers, and upon the properties and inhibition of prolyl hydroxylase, the intracellular enzyme which hyroxylates proline residues within collagen.

journal_name

Acta Trop

journal_title

Acta tropica

authors

Kagan HM

doi

10.1016/s0001-706x(00)00128-5

subject

Has Abstract

pub_date

2000-10-23 00:00:00

pages

147-52

issue

1

eissn

0001-706X

issn

1873-6254

pii

S0001-706X(00)00128-5

journal_volume

77

pub_type

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